Alcohol and Aldehyde Metabolizing Systems-IV

ISBN-13: 9781475714210 / Angielski / Miękka / 2013 / 835 str.

Ronald Thurman

Spis treści

Enzymology of Alcohol and Aldehyde Dehydrogenases and Cytochrome P-450.- Role of Hydroxyl Radicals in Microsomal Oxidation of Alcohols.- On the Possible Relationship of Cytochrome P-450 to Alcohol Metabolism: Fundamental Aspects of the Microsomal Hydroxylation System, Including Properties and Interactions of the Components.- Evolution of Aldehyde Reductase: An Immunological Approach to the Relatedness of Aldehyde Reductase from Different Species.- Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity.- On the Interaction of Human Liver Aldehyde Dehydrogenase E1 Isoenzyme with Disulfiram and Iodoacetamide.- Ethanol-Inducible Liver Cytochrome P-450 in the Rat: Relative Specificity for Ethanol Oxidation Activity in Vitro.- Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse.- Isozymes of Alcohol Dehydrogenases.- Carbon-13 Magnetic Resonance Probe of Coenzyme and Inhibitor Binding in Liver Alcohol Dehydrogenase.- Properties of Adlehyde Dehydrogenase from Chemically-Induced Rat Hepatomas and Normal Rat Liver.- Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. II. Interactions of Cytochrome P-450 with Substrates and Nadph-Cytochrome % MathType!MTEF!2!1!+-% feaagCart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGabm4yayaaDa% aaaa!3700! $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}} $$ Reductase.- Alterations of Hepatic Alcohol Metabolizing Enzyme Activities Due to Thyroid Hormones.- Genetically Mediated Responses of Microsomal Ethanol Oxidation in Mice.- In Vivo Evaluation of Ambivalent Active-Site-Directed Inactivators of Liver Alcohol Dehydrogenase.- Kinetic and Mechanistic Studies of Oxidation of Vitamin a Alcohol to Vitamin a Aldehyde by Horse Liver Alcohol Dehydrogenase. The Inhibition by Ethanol and Pyrazole.- Mechanism of Inhibition of Mixed-Function Oxidation by Ethanol.- Multifunctionality of Liver Alcohol Dehydrogenase.- The Nature and Function of Aldehyde Reductases from Rat Brain.- Mechanism of the Magnesium Ion Activation of the Catalytic Activity of Horse Liver Aldehyde Dehydrogenase.- Kinetic Studies on NADPH-Linked Aldehyde Reductase from Human Liver.- Mitochondrial Energy Transducing Membrane and Minor Pathways of Alcohol Metabolism.- Structure of Cytochrome c Oxidase.- Acetaldehyde Directly Inhibits the Conversion of Androstenedione to Testosterone in the Testes.- Microsomal N-Depropargylation of Pargyline to Propiolaldehyde, an Irreversible Inhibitor of Mitochondrial Aldehyde Dehydrogenase.- The Presence of 2,3-Butanediol in the Blood of Chronic Alcoholics Admitted to an Alcohol Treatment Center.- Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption.- Relationships Between Bilayer Lipid, Motional Freedom of Oxidoreductase Components, and Electron Transfer in the Mitochondrial Inner Membrane.- A Possible Hemoglobin Marker of Alcoholism.- Distribution of Ethanol between Blood and Dorsal Subcutaneous Air of the Rat and the Feasibility of Using this Distribution Coefficient to Estimate Blood Ethanol.- Significance of the Gastrointestinal Tract in the in Vivo Metabolism of Ethanol in the Rat.- Lipid Peroxidation in Alcoholic Liver Disease in Man.- The Effect of Duration of Alcohol Administration on the Deposition of Trace Elements in the Fetal Rat.- The Role of Folates in Methanol Toxicity.- The ATP Synthesizing System of Liver Mitochondria.- The Temperature Dependence of Respiration and ATPase in Rat Liver Mitochondria is Altered by Ethanol.- Effect of Ethanol on Hemoperfusion and O2 Sufficiency in Livers in Vivo.- Ethanol as a Selective Inhibitor of Microsomal Barbiturate Hydroxylation in Vitro and in Vivo.- Direct Effect of Ethanol on Acid Secretion in Isolated Canine Gastric Mucosa.- Effects of Chronic Ethanol Consumption on the Respiratory Chain of Rat Liver Submitochondrial Particles.- Biochemical Compartmentation and Intermediary Metabolism.- Comparative Study of the Effect of Amino Acids on Ethanol Oxidation in Isolated Hepatocytes from Starved and Fed Rats.- Ethanol Oxidation in Isolated Hepatocytes.- Contributions of Cytosolic and Mitochondrial Acetyl-CoA Syntheses to the Activation of Lipogenic Acetate in Rat Liver.- Use of 13C NMR for Investigation of Ethanol Metabolism in Perfused Liver.- Changes in Liver Inorganic Pyrophosphate Content during Ethanol Metabolism.- Acetaldehyde and Acetate Production during Ethanol Metabolism in Perfused Rat Liver.- Breath Acetaldehyde Levels after Ethanol Consumption.- Determination of Hepatic Acetaldehyde and its Biphasic Relationship to the Ethanol Concentration in Rats.- Breath Acetaldehyde: Evidence of Acetaldehyde Production by Oropharynx Microflora and by Lung Microsomes.- The Effect of Chronic Ethanol Consumption on Pathways of Ethanol Metabolism.- Aldehyde Dehydrogenase Inhibitors and Voluntary Ethanol Drinking by Rats.- Rate-Determining Factors for Ethanol Metabolism in Vivo during Fasting.- Biochemical, Morphological and Clinical Correlates of Alcoholic Liver Disease.- Isolation of a Lipocyte-Rich Fraction from Rat Liver Nonparenchymal Cells.- Effects of Chronic Ethanol Feeding on Rat Hepatocytes.- The Effect of Ethanol on the Metabolism of Prostaglandins and Related Compounds.- Alcohol Dehydrogenase in Cultured Human Skin Fibroblasts Human Fibroblast Alcohol Dehydrogenase.- Kinetics and Control of Alcohol Oxidation in Rats.- Inhibition of the Synthesis of Macromolecules by Ethanol in Regenerating Rat Liver.- Psychotropic Drug Metabolism in Fetal Alcohol Syndrome.- Chronic Ethanol Ingestion and Glycogen Metabolism in Male and Female Rats.- Effects of Alcohol on ?-Glutamyl Transpeptidase (GGTP).- The Effect of Chronic Ethanol Consumption on the Rate of Whole Animal and Perfused Liver Oxygen Consumption.- Dependence of Mitochondrial and Cytosolic ATP Systems on the Metabolic State of Perfused Rat Liver.- Stimulation of Ethanol Metabolism by Catecholamines.- Increased Biliary Glutathione Disulfide (GSSG) Release in Chronically Ethanol-Treated Rats.- The Role of Liver Cytosolic Aldehyde Dehydrogenase in Ethanol Metabolism in DBA and C57Bl Mice.- Low Acetaldehyde Levels in Blood, Breath and Cerebrospinal Fluid of Intoxicated Humans as Assayed by Improved Methods.- Alcoholic Liver Disease Associated with Increased Gamma-Glutamyltransferase Activities in Serum and Liver.- Ethanol Elimination is Inherited in the Rat.- Effect of Acute and Chronic Ethanol Intoxication on Hepatic Regeneration.- Calcium Homeostasis and Compartmentation in Liver.- Mechanism of the Swift Increase in Alcohol Metabolism (“SIAM”) in the Rat.- Neurochemistry and Neuropharmacology.- Reversal of Tolerance to Ethanol Associated with the Induction of Physical Dependence on Ethanol in the Rat.- Acetaldehyde Hydrate and Carbonic Anhydrase: Possible Roles in the Inhibition of Brain Aldehyde Dehydrogenase.- Effects of Aliphatic Alcohols and Aldehydes on Fluidity of Spin-Labeled Synaptosomal Plasma Membranes.- The Effects of Ethanol on Developing Catecholamine Neurons.- A Comparison of Behavioral and Neurochemical Effects on Ethanol and Chlordiazepoxide.- Biochemical Correlates of Tolerance in Rodents and in Drosophila. Possible Role of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Superoxide Dismutase.- Multiple Aldehyde Reductases of Human Brain.- Receptor and Membrane Function in the Alcohol Tolerant/Dependent Animal.- Cross-Tolerance between Ethanol and Morphine.- Reversal of Ethanol Tolerance and Cross-Tolerance to Pentobarbital in the Rat.- Brain Neurotransmitter Receptor Systems in Alcohol Treated Mice and in Mice Genetically Selected for Differences in Sensitivity to Alcohol.- Effect of Ethanol and Acetaldehyde on Membrane-Bound Enzymes in Rat Brain.- Tetrahydropapaveroline Inhibits Dopamine Uptake in Rat Brain Synaptosomes.- Ethanol Induced Changes on in Vitro Protein Synthesis during the Development and Maturation of Brain Tissue.