Advances in Prodrugs: Design and Therapeutic Applications

ISBN-13: 9780443156359 / Angielski

Claudiu Trandafir Supuran; Andrea Angeli; Damiano Tanini

Spis treści

Part 1 Introduction
1. Prodrugs: general concepts, prodrug design in medicinal chemistry

Part 2 activation mechanisms and related functional groups
2. Ph-sensitive prodrugs
3. Enzyme-mediated activation of prodrugs
4. Reactive oxygen species-responsive prodrugs
5. Photoactivable prodrugs
6. Antibody directed enzyme prodrug therapy (adept)
7. Self-assembling prodrugs
8. Carrier-linked prodrugs
9. Hypoxia-activated prodrugs

Part 3 application of prodrugs in the treatment of diseases
10. Antiviral and antiretroviral prodrugs
11. Prodrugs for cancer therapy
12. Prodrugs for neurodegenerative diseases
13. Prodrugs in cardiovascular therapy
14. Prodrugs for inflammatory diseases
15. Prodrugs for ocular diseases
16. Antibacterial prodrugs
17. Prodrugs against neglected diseases