Advances in Membrane Biochemistry and Bioenergetics

ISBN-13: 9781468486421 / Angielski / Miękka / 2012 / 618 str.

Opis

This book is formulated from the papers presented at the International Symposium on "Membrane Biochemistry and Bioenergetics," held at the Rensselaerville Institute, Rensselaerville, New York, August 1986, in honor of Tsoo E. King on the occasion of the 30th anniversary of reconstitution of arespiratory chain system by Professor David Keilin and Tsoo E. King. Professor Tsoo E. King, to whom this volume is dedicated, has made enormous contributions to the field of isolation and reconstitution of membrane proteins and has continued to explore the frontiers of bioener- getics. In particular, his persistent proposals on the existence of ubiquinone binding proteins from conceptualization to experimentation eventually convinced many scientists to study these proteins further . Professor King's preparation of reconstitutively active succinate dehydrogenase opened a new avenue in the fie1d of membrane bioenergetics, and his work has been greatly appreciated. The purpose of the symposium was to bring together scientists from diverse disciplines related to membrane bioenergetics to discuss the recent developments in the field. This symposium, initiated by the Capital District Bioenergetics Group, was attended by 100 scientists, 80 of whom presented their recent discoveries. The symposium was arranged in a sequence of platform lectures, poster presentations and discussion sessions so that all the participants had opportunities to discuss the subjects presented. Most of the participants contributed a chapter to this volume. We would like to express our regret to many other scientists including Professor King's friends, colleagues and students who could not attend due to various reasons.

Spis treści

Tsoo E. King.- My Teachers and I.- Reconstitution as a Research Programme: T. E. King 1956-1986.- Plenary Session.- Respiratory Chain Systems in Theory and Practice.- 1. Mitochondrial Electron Transfer.- Introductory Remarks.- Flavoproteins: Correlations of Structure and Function.- Mitochondrial Electron Transport: The Random Collision Model.- Lateral Diffusion as a Rate-Limiting Step in Mitochondrial.Electron Transport.- The Pool Function of Ubiquinone in the Mitochondrial Respiratory Chain: Role of Lateral Diffusion.- Effects of Long Chain Alkyl Compounds on Submitochondrial Particles: Mechanistic Differences between NADH and Succinate Oxidases.- Purification and Properties of the Rotenone-Insensitive NADHiQ6 Oxidoreductase from Saccharomyces cerevisiae.- An Ubiquinone-Binding Protein, A Constituent of Iron-Sulfur Fragment Isolated from Mitochondrial NADH-Ubiquinone Reductase (Complex I).- Construction of Yeast Mutants of QH2 Cytochrome c Oxidoreductase: Requirements of the 11, 14 and 17 kDa Subunitsf but Not the 40 kDa Subunitf for Enzymatic Activity.- Electron Transfer and Spectral Changes in Cytochrome b Studied in Mitochondria from Coenzyme Q-Deficient Mutants of the YeastSaccharomycescerevisiaeReconstituted with Coenzyme Q Analogues.- Structural and Functional Features of the Eleven Constituent Proteins of the Mammalian Ubiquinol: Cytochrome c Reductase.- A Mitochondrial Protein Essential for Interaction between Cardiac Cytochromes c1 and c: The Hinge Protein.- A Function of the Hinge Protein c1-c.- The Thiopropionyl Derivatives of Cytochrome c.- Monoclonal Antibodies of Mammalian Cytochrome Oxidase and its Protein Subunits.- Biochemical Characterization of Boar Sperm Cytochrome Oxidase.- Molecular Events in Cytochrome c Oxidase.- The Cyanide-Resistant Oxidase in Higher Plant Mitochondria.- 2. Bacterial-Chloroplast Electron Transfer.- Comparative Studies on the NADH-Q Oxidoreductase Segment of the Bacterial Respiratory Chain.- T. OshimaPathways of Electron Transfer in Desulfovibrio.- Studies on A Novel Flavodoxin from the Repiratory Mutant TZN-200 from Azotobacter vinelandii.- Electron Transfer Components of Mangansese Oxidizing Bacteria.- Biochemical and Genetic Approaches to Elucidating the Mechanism of Respiration and Energy Transduction inParacoccus denitrificans.- Reconstitution of Function in Fatty-Acid Inactivated Photosystem 2.- Electron Transport in the Cytochrome b6f Complex.- 3. Energy Coupling And Ion Transport.- pH-Dependence of the Maximal Velocity of Cytochrome c Oxidase: Relation to Proton and Respiratory Control.- Control of Proteoliposomal Cytochrome Oxidase: Normal and Inverted Orientations.- Cytochrome c Peroxidase Activity of Cytochrome Oxidase and its Coupling to Proton Pumping.- Characteristics of the Protonmotive Activity of the Cytochrome Chain of Mitochondria.- Dependence of the 3-OH-Butyrate Dehydrogenase and Cytochrome c Oxidase Reactions- on Intramitochondrial pH.- Role of Coupling Factor B in the FO Proton Channel.- ATP Synthesis and Ion Gradients in the Methanogenic Bacteria.- Energy Transfer in Solute Carrier Transport.- Interaction of Quinine with Mitochondrial K+ Transport Mechanisms.- Outer Membrane Lysis Increases Accessibility of Cationic Drugs to the Inner Mitochondial Membrane.- 4. Biophysical Techrliques.- Optical and X-Ray Techniques in the Study of Rapid Ligand Binding: A Ligand “Docking” Site in the Reaction of Mb and CO at 40 K.- X-Ray Absorption Studies of Oriented Cytochrome Oxidase.- Newly Developed Time Resolved EPR Techniques for the Study of Cytochrome c Oxidaie.- EPR and Electron Spin Echo Studies of Iron-Sulfur Clusters S-I and S-2 in Bovine Heart Succinate Dehydrogenase.- New Avenues in Electron Microscopy of Transmembranous Biomolecular Assemblies.- Structural Influences on the Electrochemisty of Ubiquinone.- 5. Related Enzyme Systems.- Enzymatic Synthesis of Acetono-CoA: A Competitive Inhibitor of Acetyl-CoA with Citrate Synthase.- Purification and Properties of Two Isoenzymes of Tench Liver Arginase.- Enzymes at Oil-Water Interfaces and in Organic Solvents.- Conformational Changes at the Active Site of D-Glyceraldehyde-3-Phosphate Dehydrogenase during Unfolding in Guanidine Solution.- Acute Stimulation by Peptide Hormones of Mitochondrial Steroid Hormone Synthesis: Production of A Similar Protein in Three Steroidogenic Tissues.- Interaction of Steroid Substrates with Cytochrome P-450C21-Proteoliposomes.- Regulation of Cholestrol 7 ?-Hydroxylase.- 6. Clinical Aspects.- An Overview of Biochemical and Clinical Research on Coenzyme Q with Emphasis on Cardiomyopathy and Muscle Dystrophy.- Membrane Damage Provoked by Lipid Peroxides.- Oxidation-Reduction Associated with Inhaled NO2 Absorption.- The Reconstitution of Biologically Active Glycoproteins into Large Liposomes: Use as a Delivery Vehicle to Animal Cells.- Symposium Participants.