Advanced Issue Resolution in Safety Pharmacology

ISBN-13: 9780128122068 / Angielski / Twarda / 2018 / 360 str.

Mary Jeanne Kallman; Michael Pugsley

Spis treści

1. Introduction to Issue Resolution 2. Selection of Nontraditional Species for Issue Resolution Studies 3. The Use of Modeling to Facilitate Decision-Making in Safety Pharmacology Assessments 4. Issue Resolution of Drug-Induced Breathing Instability and the Occurrence of Apneic Events 5. The Impact of Drug-Induced Effects on the Gastrointestinal System: Challenges and Issue Resolution for Safety Pharmacology 6. Sleep and Sleep Disruption 7. Self-Injurious Behavior in Clinical and Preclinical Populations: Description, Etiology, and Management 8. Approaches for Early Identification of Abuse Potential Liability 9. Issue Resolution of Motor Deficits and Stereotypies 10. Issue Resolution Related to Convulsive Profiles 11. Utility of Progressive Ratio Schedules of Reinforcement in Abuse Potential Assessments 12. Application of Imaging in the Resolution of Safety Pharmacology Issues 13. Cardiovascular Safety Pharmacology Issue Resolution 14. Use of In Vitro Models in Drug Development and Issue Resolution 15. Future Needs in Issue Resolution of Problems That Arise in Drug Development