Adhesion in Leukocyte Homing and Differentiation

ISBN-13: 9783642782558 / Angielski / Miękka / 2011 / 260 str.

Dominique Dunon; Charles R. MacKay; Beat A. Imhof

Opis

This book presents the current knowledge on the structure and function of the major families of cell adhesion molecules, the integrins, the selectins, the immunoglobulins superfamily and CD44, concentrating on their role in the immune system. Complex interactions between the members of these families mediate diverse adhesion functions, including leukocyte-leukocyte interactions, lymphocyte homing, inflammation, and lymphocyte-stromal cell interaction during homopoiesis. A great deal of emphasis is placed on the regulatory elements that control the expression and function of adhesion molecules: Cytokines not only induce the expression of certain adhesion molecules, but may also modify their functional status. A number of chapters discuss the migration of lymphocytes between hemopoietic organs such as the thymus, lymph nodes, Peyer's patches and spleen, and other chapters focus on the changes in leukocyte migration during an inflammatory response. In summary, this book introduces new aspects of cell adhesion on the molecular and biological level.

Spis treści

The Dominance of Antigen-Specific Receptors in Antigen-Specific Immune Responses.- I Adhesion Molecules.- Integrins and Their Ligands.- Platelet Endothelial Cell Adhesion Molecule (CD31).- CD44: A Multitude of Isoforms with Diverse Functions.- The Selectins and Their Ligands.- II Regulation of Leukocyte-Endothelial Cell Adhesion.- A Model of Leukocyte Adhesion to Vascular Endothelium.- Regulation of Adhesion Receptor Expression in Endothelial Cells.- Regulation of Leukocyte Recruitment by Proadhesive Cytokines Immobilized on Endothelial Proteoglycan.- III Lymphoid Cell Homing Mechanisms.- Migration of Activated Lymphocytes.- The Peyer’s Patch Homing Receptor.- Pro-T Cell Homing to the Thymus.- Quantitative Analysis of Lymphocyte Fluxes In Vivo.- Lymphocyte Recirculation and Life Span In Vivo.- IV Leukocyte Homing to Inflamed Tissues.- The Contributions of Integrins to Leukocyte Infiltration in Inflamed Tissues.- Regulation of Adhesion and Adhesion Molecules in Endothelium by Transforming Growth Factor-?.- Transendothelial Migration.- V Adhesion Molecules in Differentiation and Activation of Lymphocytes.- CD44 and Other Cell Interaction Molecules Contributing to B Lymphopoiesis.- CD4, CD8, and CD2 in T Cell Adhesion and Signaling.- Activation and Inactivation of Adhesion Molecules.