Adenosine Receptors in Health and Disease

ISBN-13: 9783662501627 / Angielski / Miękka / 2016 / 652 str.

Constance N. Wilson; Constance N. Wilson; S. Jamal Mustafa

Opis

Adenosine receptors are important novel molecular targets in disease and drug discovery. As a result of investigations into these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials.

Spis treści

to Adenosine Receptors as Therapeutic Targets.- A1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers.- Recent Developments in Adenosine A2A Receptor Ligands.- Recent Developments in A2B Adenosine Receptor Ligands.- Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering.- Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology.- Adenosine Receptors and Reperfusion Injury of the Heart.- Adenosine Receptors and Inflammation.- A1 Adenosine Receptor: Role in Diabetes and Obesity.- A3 Adenosine Receptor: Pharmacology and Role in Disease.- Adenosine Receptors and Asthma.- Adenosine Receptors, Cystic Fibrosis, and Airway Hydration.- Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis.- Adenosine Receptors and Cancer.- Adenosine Receptors and the Kidney.- Adenosine Receptors and the Central Nervous System.- Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration.- Adenosine A2A Receptors and Parkinson’s Disease.- Adenosine Receptor Ligands and PET Imaging of the CNS.