Chromatin and Disease

ISBN-13: 9789048173747 / Angielski / Miękka / 2010 / 458 str.

Tapas K. Kundu; Dipak Dasgupta

Opis

It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling."

Spis treści

PART I: Chromatin Structure, Dynamics and Disease 1 Structural organization of dynamic chromatin in humans. Kohji Hizume, Shige H. Yoshimura and Kunio Takeyasu 2 Chromatin Remodeling: Action and Reaction. Parul Choudhary and Patrick Varga-Weisz 3 Regulation of Chromatin Structure and Transcription by Poly (ADP- Ribose) Polymerase- I: Possible targets for drug based therapies. David A. Wacker, Kristine M. Frizzell, and W. Lee Kraus 4 Histone variant nucleosomes: structure, function and implication in disease. Mathieu Boulard, Philippe Bouvet, Tapas K Kundu and Stefan Dimitrov 5 Histone variants and complexes involved in their exchange. Thomas Kusch and Jerry L. Workman 6 Histone chaperones in chromatin dynamics: Implication in disease manifestation. Jayasha Shandilya, Shrikanth Gadad, V.Swaminathan and Tapas K. Kundu 7 Function of the histone chaperone Nucleolin in diseases. Sébastien Storck, Manu Shukla, Philippe Bouvet 8 Chromatin as a target for the DNA binding anti-cancer drugs. Parijat Majumder, Suman K. Pradhan, Pukhrambam Grihanjali Devi, Sudipta Pal and Dipak Dasgupta PART II: Nonhistone Proteins, Sites for Epigenetic Marks: link to Disease. 9 Reversible acetylation of Non Histone proteins: Role in cellular function and disease. Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya and Tapas K. Kundu 10 MARs and MARBPs: Key modulators of gene regulation and disease manifestation. Samit Chattopadhyay and Lakshminarasimhan Pavithra PART III : Epigenetic Modifications of Chromatin : Implication in Disease and Therapeutics. 11 Aberrant forms of acetyltransferases in human diseases. Olivier van Beekum and Eric Kalkhoven 12 Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools? Anne-Laurence Boutillier, CarolineRouaux, Panteleeva 13 Function of MYST family Histone acetyltransferases and their link to diseases. Nikita Avvakumov and Jacques Cote 14 Role of histone phosphorylation in chromatin dynamics and its implication in diseases. Masaya Oki, Hitoshi Aihara and Takashi Ito 15 Function of euchromatic histone H3K9 methyltransferases, G9a/GLP. Yoichi Shinkai 16 Histone acetylation and methylation: Combinatorial players for transcriptional regulation Woojin An 17.Chromatin modifying enzymes and HIV gene expression. Vincent Quivy, Stéphane de Walque, and Carine Van Lint 18.Small Molecule Modulators in Epigenetics: Implication in gene expression and therapeutics. V.Swaminathan, B.A.Ashok Reddy, Selvi R, Sukanya.M.S. and Tapas K. Kundu Index