Heterocyclic Antitumor Antibiotics

ISBN-13: 9783540309826 / Angielski / Twarda / 2006 / 252 str.

Moses Lee; D. P. Arya; T. Brown

Opis

The series "Topics in Heterocyclic Chemistry" will present critical reviews on "Heterocyclic Compounds" within topic related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.

Recenzje

From the reviews:

"Heterocyclic antitumor antibiotics represent a broad class of natural products that are of widespread interest ... . Thus, a well-written, up-to-date account of progress in the study of such compounds is expected to be well received. ... this monograph certainly has sufficient scientific value to merit inclusion in most academic libraries and in industrial laboratories concerned with antibacterial and anticancer agent discovery. Individual researchers, on the other hand, might first wish to weigh the extent to which this far-ranging collection of reviews deals sufficiently with topics of specific interest to their research groups before acquiring a personal copy." (Gary I. Dmitrienko, Journal of the American Chemical Society, Vol. 129, 2007)

Spis treści

T. Brown, H. Holt Jr., M. Lee: Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin.-

J.T. Gupton: Pyrrole Natural Products with Antitumor Properties.-

Brian E. Love: Synthesis of Carbolines Possessing Antitumor Activity.-

D.P. Arya: Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action.-

M. Daneshtalab: Novel Synthetic Antibacterial Agents.-

S.N. Maiti, R.P. Kamalesh Babu, R. Shan: Overcoming Bacterial Resistance: Role of ß-Lactamase Inhibitors