Industrial Microbiology

ISBN-13: 9783527340354 / Angielski / Miękka / 2020 / 424 str.

David B. Wilson; Hermann Sahm; K. Peter Stahmann

Spis treści

HISTORICAL OVERVIEW AND FUTURE PERSPECTIVEUse of fermentation procedures prior to the discovery of microorganisms (Neolithic Era = New Stone Age until 1850)Investigation of microorganisms and beginning of industrial microbiology (1850 until 1940)Development of new products and processes: antibiotics and other biomolecules (after 1940)Genetic engineering as successful tool for industrial microorganisms (after 1980)Future perspectives: Synthetic microbiologyBIOPROCESS ENGINEERINGIntroductionNon-structured modelsOxygen transportHeat generating aerobic processesProduct recoveryModeling and simulation of reactor behaviorScale-upFOODFermented foodsMicroorganisms and metabolismYeast fermentations - Industrial application of Saccharomyces speciesVinegar - Incomplete ethanol oxidation by acetic acid bacteria such as Gluconobacter oxidansBacterial and mixed fermentations- Industrial application of lactic acid bacteria, with or without yeast or moldsFungi as foodConclusions and outlookINDUSTRIAL ALCOHOLS AND KETONESIntroductionEthanol synthesis by Saccharomyces cerevisiae and Clostridium autoethanogenum1,3-Propanediol synthesis by Escherichia coliButanol and isobutanol synthesis by clostridia and yeastAcetone synthesis by solventogenic clostridiaOutlookORGANIC ACIDS IntroductionCitric acidLactic acidGluconic acidSuccinic acidItaconic acid Downstream options for organic acidsPerspectivesAMINO ACIDSIntroductionProduction of amino acidsL-Glutamate synthesis by Corynebacterium glutamicumL-LysineL-Threonine synthesis by Escherichia coliL-PhenylalanineOutlookVITAMINS, NUCLEOTIDES, CAROTENOIDSApplication and economic impactL-Ascorbic acid (vitamin C)Riboflavin (vitamin B2)Cobalamin (vitamin B12)Purine nucleotidesß-CarotenePerspectivesANTIBIOTICS AND PHARMACOLOGICALLY ACTIVE COMPOUNDSMicrobial substances active against infectious disease agents or affecting human cellsbeta-LactamsLipopeptidesMacrolidesTetracyclinesAminoglycosidesClaviceps alkaloidsPerspectivesPHARMACEUTICAL PROTEINSHistory, main areas of application and economic importanceIndustrial expression systems, cultivation and protein isolation and legal frameworkInsulinsSomatropinInterferons ? Application and manufacturingHuman granulocyte colony-stimulating factorVaccinesAntibody fragmentsEnzymesPeptidesView - Future economic importanceENZYMESFields of application and economic impactsEnzyme discovery and improvementProduction process for bacterial or fungal enzymesPolysaccharide-hydrolyzing enzymesEnzymes used as cleaning agentsFeed supplements - phytases Enzymes for chemical and pharmaceutical industryEnzymes as highly selective tools for research and diagnosticsPerspectivesMICROBIAL POLYSACCHARIDESIntroductionHeteropolysaccharidesHomopolysaccharidesPerspectivesSTEROIDSFields of applications and economic importanceAdvantages of biotransformations during production of steroidsDevelopment of production strains and production processesApplied types of biotransformationSynthesis of steroids in organic-aqueous biphasic systemsSide chain degradation at phytosterols by Mycobacterium to gain steroid intermediatesBiotransformation of cholesterol to gain key steroid intermediates11-Hydroxylation by fungi during synthesis of corticosteroidsdelta1-dehydrogenation by Arthrobacter for the production of prednisolone17-keto reduction by Saccharomyces in testosterone productionDouble bond isomerization of steroidsPerspectivesBIOLEACHINGMineral-oxidizing acidophilic bacteria dissolve metals from sulfide ores Bioleaching of copper, nickel, zinc and cobaltGold UraniumPerspectivesWASTEWATER TREATMENT PROCESSESIntroductionBiological treatments for carbon, nitrogen and phosphorus removalWastewater treatment processes Advanced wastewater treatment Future perspectives

O autorze

David Wilson, PhD, was a Professor of Biochemistry, Molecular and Cell Biology at Cornell University in Ithaca (USA).Hermann Sahm, PhD, is Emeritus Professor of Biotechnology at the University of Düsseldorf (Germany). Peter Stahmann, PhD, is Professor for Technical Microbiology at Brandenburg University of Technology Cottbus-Senftenberg in Senftenberg (Germany). Mattheos Koffas, PhD, is Professor of Biology at Rensselaer Polytechnic Institute in Troy (USA).