Metal-Carbon Bonds in Enzymes and Cofactors

ISBN-13: 9783110442793 / Angielski / Twarda / 2015 / 530 str.

Astrid Sigel;Helmut Sigel;Roland K.O. Sigel

Opis

The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently appreciated. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. MILS-6, written by 20 experts, summarizes the most recent insights into this fascinating topic.

Spis treści

From the Content:

• Organometallic Chemistry of B12 Coenzymes
• Cobalamin- and Corrinoid-Dependent Enzymes
• Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase
• Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases
• Structure and Function of [NiFe]-Hydrogenases
• Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases
• Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase
• The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide
• Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site
• Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc
• The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds
• Computational Studies of Biooganometalllic Enzymes and Cofactors

O autorze

Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.