Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics

ISBN-13: 9781588295149 / Angielski / Twarda / 2006 / 412 str.

Joyce Tombran- Tink; Joyce Tombran-Tink; Colin J. Barnstable

Opis

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.

Recenzje

From the reviews:

"Colin J. Barnstable and co-workers have undertaken the task to present an up-to-date collection including presentations on clinical and mechanistic data as well as current therapeutic applications. The 412-page hardback book includes numerous black-and-white pictures as well as several illustrations. ... The book ... will surely find a place not only for the use of basic scientists but could be of interest for the clinician trying to understand the background on angiogenesis research." (Antonia Joussen, Graefes Archive for Clinical and Experimental Ophthalmology, Issue 246, 2008)

Spis treści

I. Angiogenic Diseases Age-Related Macular Degeneration Curtis L. Hagedorn and Ron A. Adelman Endogenous Angiogenic Inhibitors in Diabetic Retinopathy Jian-Xing Ma and Sarah X. Zhang Corneal Angiogenesis Trevor R. Carmichael Polypoidal Choroidal Vasculopathy Nahoko Ogata and Kanji Takahashi Myopic Choroidal Neovascularization Kyoko Ohno-Matsui and Takashi Tokoro Mechanisms of the Formation and Stability of Retinal Blood Vessels Jonathan Stone, Trent Sandercoe, and Jan Provis Neovascular Glaucoma James C. Tsai and M. Bruce Shields Eales' Disease Jyotirmay Biswas Angiogenesis and Ocular Tumorigenesis Nader Sheibani and Daniel M. Albert Genetics of Ocular Vascular Disease Jacquie Greenberg, Ari Ziskind, and Stephen P. Daiger II. Endogenous Promoters and Inhibitors of Angiogenesis Vascular Endothelial Growth Factor and Retinal Diseases Sam Dahr and Karl G. Csaky The Role of Fibroblast Growth Factors in Ocular Angiogenesis Andreas Bikfalvi and Sophie Javerzat Control of Neovascularization and Cell Survival in the Eye by PEDF Joyce Tombran-Tink and Colin J. Barnstable Thrombospondin: Guarding the Clear View Arin Aurora and Olga V. Volpert Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinases Bela Anand-Apte Integrins in Ocular Angiogenesis Matthew R. Ritter and Martin Friedlander Ocular Inflammation and Neovascularization Chi-Chao Chan and Robert B. Nussenblatt III. Therapeutics and Delivery for Angiogenic Eye Diseases Anti-VEGF Therapies for Diseases of the Retina and Choroid Ming Lu and Donald J. D'Amico Anecortave Acetate: A Novel Ocular Angiostatic Agent Stella M. Robertson, Alberta A. Davis, David C. Dahlin, and Abbot F. Clark Gene Therapy for Neovascular Retinopathies Brian J. Raisler, Kenneth I. Berns, and William W. Hauswirth Noninvasive Delivery of DNA Into the Eye John M. Nickerson, R. Keith Shuler, Jr., John B. Davies, Phyllis K. Dioguardi, Steven M. Wolchok, Vincent T. Ciavatta, Jeffrey H. Boatright, and Henry F. Edelhauser Novel Drug Delivery Systems for Posterior Segment Ocular Disease Heather Sheardown and W. Mark Saltzman Index

Blurb

The recent intense study of pathogenic ocular angiogenesis-an abnormal growth of blood vessels in the eye responsible for the major blinding diseases throughout the world-has yielded an overwhelming flood of scientific findings, novel insights, and possible future therapeutic approaches. In Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize these developments to present a comprehensive review of what is known about angiogenesis, its role in blinding diseases, and the mechanisms leading to progressive vessel dysfunction. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.