Mucus in Health and Disease--II

ISBN-13: 9781461592563 / Angielski / Miękka / 2012 / 441 str.

Eric Chantler

Opis

This second International Symposium on Mucus in Health and Disease once again brings together basic scientists such as Biochemists, Anatomists, Biologists and Clinicians who are dealing with aspects of mucus in the various tracts of the body where it is of such great functional importance. It is fitting that the meeting should take place at Manchester University where there is so much activity in this field and our grateful thanks are due to Or Eric Chantler for his untiring efforts in organising this meeting. At the first Mucus meeting, Sir Francis Avery Jones stated "this is a subject which will justify further Symposia, both local and international." As he predicted, this meeting succeeds the first and adds further to our progress in understanding the complex and unique structure and function of the mucus secretion in its various sites of the body. Much was learned from the first meeting and it is hoped that the second will be an appropriate successor to it. The emphasis in this meeting has been to encourage discussion and the presentation of research material. In this respect, review articles have been kept to a minimum. The structure of the Conference has been organised around eight keynote addresses: one on the biosyn- thesis of the general mucus glycoproteins and another on its physical properties. Other keynote papers are on the biochemical and clinical aspects of mucus in the respiratory, gastrointestinal and urogenital tracts by recognised authorities in these subjects.

Spis treści

Mucus Biosynthesis: Immunological and Rheological Properties.- Biosynthesis of Mucus Glycoproteins.- Antigenicity of Mucins — their Relevance to Tumour Associated and Stage Specific Embryonic Antigens.- Structure and Antigenic Diversity in Mucin Carbohydrate Chains.- The Use of Radioimmunoassay as a Probe of the Antigenic Determinants and Structure of Human Small Intestinal Mucin.- Trisaccharides from Blood Group A1 and A2 Mucous Glycoproteins.- Structure & Function of Mucus.- Modification of the Rheological Properties of Mucus by Drugs.- A Rheological Study of Mucus — Antibiotic Interactions.- Biopolymer Induced Changes in Mucus Viscoelasticity.- Evaluation of Mucolytic Activity Using a Purified Mucus Glycoprotein Gel.- Rheological Studies on Native Pig Gastric Mucus Gel.- Mucus Hydration: A Donnan Equilibrium Controlled Process.- Dissolution of Tetracycline Hydrochloride in Mucin Solutions.- The Use of High Resolution Carbon13 NMR in the Study of Mucus Glycoproteins.- Gastero-Intestinal Mucus.- Structure and Physiology of Gastro-Intestinal Mucus.- Studies Upon the Secretion of Gastric Mucus from Normal Subjects.- The Neutral Carbohydrate Chains of Gastric and Duodenal Mucosubstances.- The Composition of a Macromolecular Extract of Combined Human Body and Fundic Mucosa.- Differences in Mucus Glycoproteins of Small Intestine from Subjects With and Without Cystic Fibrosis.- Gastric Mucosubstances and Benign Gastric Ulceration.- Reduction by Mercaptoethanol and Proteolysis of the Non-Glycosylated Peptide Region of Pig Gastric Mucus GLycoprotein.- An Insoluble Mucin Complex from Rat Small Intestine.- Composition and Structure of Rat Brunner’s Glands and Gastric Mucous Glycoprotein.- Effect of Lysolecithin on the Constituents of Gastric Mucus.- Synthesis and Secretion of Glycoproteins by Isolated Rat Small Intestinal Epithelial Cells.- Ultracentrifugation of Salivary Mucins.- The Gastric “Mucus-Bicarbonate” Barrier: Effect of Luminal Acid on HCO?3 Transport by Amphibian Fundic Mucosa In Vitro.- Studies of the Protective Properties of Gastric Mucus.- Studies of the pH Gradient Across the Mucus on Rat Gastric Mucosa In Vivo and Across Human Gastric Mucosa In Vitro.- Restriction of Hydrogen and Sodium Ion Diffusion in Porcine Gastric Mucin: a Concentration Dependent Phenomena.- Mucus and Gastric Acid-Bicarbonate Interaction.- Clinical Aspects of Gastro-Intestinal Mucus.- Ultrastructural Alterations in the Colonic Mucus Layer During Carcinogenesis: A Scanning Electron Microscopy Study.- Gallbladder Mucin Glycoprotein Hypersecretion in Experimental Cholelithiasis: Role of Mucin Gel in Nucleation of Cholesterol Gallstones.- Gastric Mucus Degradation In Vivo in Peptic Ulcer Patients and the Effects of Vagatomy.- Histochemical Changes in Mucus in Duodenal Ulceration.- Protection Against Nematodes by Intestinal Mucus.- The Intestinal Mucus Barrier to Parasites and Bacteria.- Cervical Mucus.- Structure and Function of Cervical Mucus.- Control of Human Cervical Mucin Glycosylation by Endogenous Fucosyl and Sialyltransferases.- Cyclic Changes in Glycoprotein Synthesis and Secretion by the Human Endocervix.- Carbohydrate Chains of Human Pre- and Post Ovulatory Cervical Mucous Glycoprotein.- Isolation and Purification of the Mucin Component of Human Cervical Mucus.- Speed — Dependent Sedementation — Velocity of Human Cervical Mucins in the Analytical Untracentrifuge.- Endocervical Changes in the Guinea Pig After Treatment with 17B Oestradiol and 9, 10. Dimethylbenzanthracene.- Histochemical Alterations in the Uterine Endocervical Mucosa in Different Phases of the Normal Menstrual Cycle and in the Altered Cycle.- A Preliminary Report on the Intracervical Contraceptive Device — Its Effect on Cervical Mucus.- A Scanning Electron Microscopic Study of Human Cervical Mucus.- A Freezing Artefact Associated with the Preparation of Mucin for Examination Using the Scanning Electron Microscope.- Cervical Mucus: its Physiological Role & Clinical Significance.- The Mechanisms and Analysis of Sperm Migration Through Cervical Mucus.- Spermatozoal Velocity in Human Cervical Mucus Measured by Laser Doppler Velocimetry.- Respiratory Mucus.- Respiratory Mucus: Structure, Metabolism and Control of Secretion.- Characteristics of Human Bronchial Mucus Glycoproteins Prepared in the Absence of Reducing Agents.- Isolation and Characterisation of Neutral Oligosaccharides from Human Bronchial Glycoproteins.- Macromolecular Composition of Secretions Produced by Human Bronchial Expiants.- Characterisation of Sol and Gel Phases of Infected and Mucoid Sputum Samples from Chronic Bronchitic Patient.- The Effects of Low Molecular Weight Mucus Modifying Substances on the Appearance of Mucin Gels in the Scanning Electron Microscope.- Clinical Aspects of Respiratory Mucus.- Chemical Composition of Pathological Human Tracheobronchial Mucus Collected by Fiberoptic Bronchoscopy.- Spinnability and Transport Properties of Sputum in Chronic Bronchitis.- The Mechanisms and Control of Bronchial Mucus Cell Hyperplasia.- The Role of Mucociliary Transport in the Pathogenesis of Chronic Obstructive Pulmonary Disease.- Regional Variations of Mucus Clearance in Normal and in Bronchitic Mammalian Airways.- The Development of an In Vivo Model for the Evaluation of Drugs Affecting Tracheal Mucus.- Effect of S-Carboxymethylysteine on the Biophysical and Biochemical Properties of Mucus in Chronic Bronchitics.- Stimulation of Nasal Mucus Secretion in the Rabbit.