Protein Glycosylation

ISBN-13: 9781461372417 / Angielski / Miękka / 2012 / 508 str.

Roslyn M. Bill; Leigh Revers; Iain B. H. Wilson

Opis

Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology.
Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.

Spis treści

Contributors. Abbreviations. Foreword. Acknowledgements. Sugars and Proteins: Getting It Together. Sugars and Proteins: Why They Get It Together. Sugars and Proteins: How They Get it Together. Core Issues: Building the Groundwork for N-Linked Sugars. Branching Out: Constructing the Antennae of N-Linked Sugars. And What About O-Linked Sugars? Adding the Finishing Touches: Terminal Elaborations. Expect the Unexpected: Unfamiliar Glycosylations. Complementing the Cell: Glycoform Synthesis in Vitro. Icing on the Cake: Summary and Future Directions. Index.