Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

ISBN-13: 9781461372028 / Angielski / Miękka / 2012 / 294 str.

Emel Arinc; John B. Schenkman; Ernest Hodgson

Opis

The NATO Advanced Study Institute of "Molecular and Applied Aspects of Oxida- tive Drug Metabolizing Enzymes" was held in Tekirova, Antalya, Turkey, from August 31 to September 11, 1997. This Institute was the third of a series of the NATO ASIs on a similar topic relating to the enzymes of oxidative metabolism of xenobiotics. The first NATO ASI in this series, entitled "Molecular Aspects of Monooxygenases and Bioactiva- tion of Toxic Compounds" (NATO ASI Series A: Life Sciences, Vol. 202), was held in

Spis treści

The Fate of Xenobiotics in the Body; Enzymes of Metabolism; J.B. Schenkman. Protein-Protein Interactions in the P450 Monooxygenase System; J.B. Schenkman, et al. Structures of Mitochondrial P450 System Proteins; I. Hanukoglu. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs); E. Hodgson, et al. Expression and Regulation of Flavin-Containing Monooxygenases; R.M. Philpot, et al. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism; M. Eichelbaum. Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism; F.J. Gonzalez. Clinical Aspects of Polymorphic Drug Metabolism in Humans; M. Eichelbaum. Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and Glutathione S-Transferase M1 and Cancer Susceptibility in the Human; M. Watanabe. Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance; E. Hodgson, et al. Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals; S.L. Kelly, et al. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity; R.M. Philpot. Importance of Drug Metabolism in Drug Discovery and Development; R. Gasser. 7 additonal articles. Index.