Free Radicals in Ophthalmic Disorders

ISBN-13: 9781420044331 / Angielski / Twarda / 2008 / 232 str.

Manfred Zierhut; Enrique Cadenas; Narsing Rao

Opis

Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed it will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through metabolism. However, sometimes the body s immune system will create them on purpose to neutralize viruses and bacteria. Free radicals are implicated in many ophthalmic disorders including uveitis, optic nerve damage, retinal ischemia, and macular degeneration. Free Radicals in Ophthalmic Disorders presents the most current knowledge pertaining to the role of free radicals/oxidants in ocular disorders, and the use of antioxidants in the prevention of these disorders. Written by today s leading ocular scientists and clinicians, Free Radicals in Ophthalmic Disorders:

• gives comprehensive coverage of the role of free radicals/oxidants in ocular disorders
• covers the use of antioxidants to prevent oxidative stress and ocular tissue damage
• examines external factors that may result in the stimulation and heightened occurrence of free radicals/oxidants

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Spis treści

Free Radical Biology, Mitochondrial Functions and Nitric Oxide. Antioxidants and Modulation of cardiovascular Disease. Nitric Oxide-Related Oxidants in Health and Disease. Modulation and Determination of cellular glutathione Concentrations. Oxidants in Corneal Diseases. Involvement of oxidative Stress in the Pathogenesis of Glaucoma. Oxidative Stress and Cataract. Nitric Oxide in Experimental autoimmune uveoretinitis. TNF activation and nitric oxide production in EAU. Peroxynitrite and ocular inflammation. Melanin and Oxidative stress. Are Antioxidants useful in diabetic Retinopathy? Macular Degeneration: The Role of Reactive Oxygen Species. Retinal ischemia and oxidative stress. Reduction of oxidative Stress in retinal Disease. Oxidative stress and uveitis.

O autorze

Manfred Zierhut, Enrique Cadenas, Narsing Rao