In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The...
In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constitu...
This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology
focuses on important biological...
This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of anti...
Covers antioxidants in beverages and herbal products, nitric oxide and selenium. This book highlights research on food-derived antioxidants and biomarkers; vitamins E and C; coenzyme Q; carotenoids, flavoroids and other polyphenols; antioxidants in beverages and herbal products; and, the thiol antioxidants glutathione and lipoic acid.
Covers antioxidants in beverages and herbal products, nitric oxide and selenium. This book highlights research on food-derived antioxidants and biomar...
This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants Featuring the research of over 55 experts in the area, Understanding the Process of Aging
covers the functions of nitric oxide and peroxynitrite in mitochondria
integrates several views on the role of mitochondria in the development of...
This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular...
Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP, firmly establishing its role as a physiological mediator. Over the last ten years, still further roles have been discovered that relate to nitric oxide s unique ability to interact with and modify a wide variety of other molecules and regulators...
Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientis...
Emphasizes the efficacy of synthetically occurring compounds in the management of free radical-mediated illnesses. The text details the design, development and delivery of therapeutic antioxidants used in the treatment of pathophysiological disorders, from amylotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) to Alzheimer's disease.
Emphasizes the efficacy of synthetically occurring compounds in the management of free radical-mediated illnesses. The text details the design, develo...
Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splitting bond. After a free radical is formed it will continue to attack other molecules, which usually results in the damage of tissue or destruction of a healthy cell. Free radicals arise normally through metabolism. However, sometimes the body s immune system will create them on purpose to neutralize viruses and bacteria. Free radicals are implicated in many ophthalmic disorders including uveitis, optic nerve damage, retinal ischemia, and macular...
Free radicals are molecules with an unpaired electron in the outer shell or an electron that was damaged from either attack or from a poor splittin...
The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological and pathological processes. This discovery has ignited enormous interest in the scientific community. When generated at low levels, NO is a signaling molecule, but at high concentration, NO is a cytotoxic molecule. The physiological and pathological processes of NO production and metabolism and its targets, currently areas of intensive research, have important pharmacologic implications for health and disease.
The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological a...
The Nobel Prize was awarded in Physiology or Medicine in 1998 to Louis J. Ignarro, Robert F. Furchgott and Ferid Murad for demonstrating the signaling properties of nitric oxide. Nitric oxide (NO) is one of the few gaseous signaling molecules and is a key biological messenger that plays a role in many biological processes. NO research has led to new treatments for treating heart as well as lung diseases, shock and impotence. (Sildenafil, popularly known by the trade name Viagra, enhances signaling through NO pathways.) Scientists are currently testing whether NO can be used to stop the growth...
The Nobel Prize was awarded in Physiology or Medicine in 1998 to Louis J. Ignarro, Robert F. Furchgott and Ferid Murad for demonstrating the signaling...
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK), H. Robert Horvitz (US)and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. *Provides the necessary, trusted...
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK), H. Robert Horvitz (US)and John E. Sulston (UK) "for their discoveri...
