Routes to Essential Medicines: A Workbook for Organic Synthesis

ISBN-13: 9781119722861 / Angielski / Miękka / 2021 / 512 str.

Peter J. Harrington

Spis treści

Introduction xivAbout the Companion Website xviiA 1Abacavir 1Acetazolamide 3Acetylcysteine 4Acetylsalicylic Acid 4Acyclovir 5Albendazole 6Allopurinol 7Amidotriazoate 8Amikacin 9Amiloride 114-Aminosalicylic Acid 12Amiodarone 13Amitriptyline 15Amlodipine 16Amodiaquine 17Amoxicillin 18Ampicillin 20Anastrozole 21Artemether 23Artesunate 24Ascorbic Acid 26Atazanavir 27Atracurium Besylate 29Atropine 32Azathioprine 34Azithromycin 35Aztreonam 37B 40Beclomethasone Dipropionate 40Bedaquiline 45Bendamustine 47Benznidazole 49Benzoyl Peroxide 50Benzyl Benzoate 51Betamethasone 52Bicalutamide 56Biperiden 57Bisoprolol 58Budesonide 59Bupivacaine 62C 63Caffeine 63Calcium Folinate/Folinic Acid 64Capecitabine 65Carbamazepine 67Cefalexin 68Cefazolin 69Cefepime 71Cefixime 73Cefotaxime 75Ceftaroline 77Ceftazidime 81Ceftriaxone 84Chlorambucil 86Chloramphenicol 87Chlorhexidine 89Chloroquine 90Chloroxylenol 91Chlorpromazine 92Ciprofloxacin 93Cisplatin, Carboplatin, Oxaliplatin 94Clarithromycin 97Clindamycin 99Clofazimine 100Clomifene 101Clomipramine 102Clopidogrel 103Cloxacillin 105Clotrimazole 106Clozapine 107Codeine 108Colecalciferol 109Cyclizine 112Cyclophosphamide 113Cycloserine 114Cytarabine 114D 116Dacarbazine 116Daclatasvir 117Dapsone 119Darunavir 120Dasabuvir 122Dasatinib 124Delamanid 126Desmopressin 129Dexamethasone 131Diazepam 136Diethylcarbamazine 137Dihydroartemisinin 139Diloxanide Furoate 140Dimercaprol 141Docetaxel 141Docusate Sodium 145Dolutegravir 145Dopamine 147Doxycycline 148E 150Efavirenz 150Eflornithine 152Emtricitabine 153Enalapril 155Entecavir 158Ephedrine 160Epinephrine 160Ergocalciferol 162Ergometrine 163Estradiol Cypionate 164Ethambutol 166Ethinylestradiol 166Ethionamide 167Ethosuximide 169Etonogestrel 169Etoposide 173F 175Fentanyl 175Fluconazole 176Flucytosine 177Fludarabine Phosphate 177Fludrocortisone Acetate 179Fluorouracil 180Fluoxetine 181Fluphenazine 182Folic Acid 184Fomepizole 185Formoterol 186Fosfomycin 189Furosemide 191G 192Gemcitabine 192Gliclazide 194Glutaral 195Glyceryl Trinitrate 196H 197Haloperidol 197Halothane 199Hydralazine 199Hydrochlorothiazide 200Hydrocortisone 200Hydroxycarbamide 203Hydroxychloroquine 204Hyoscine Butylbromide 205I 207Ibuprofen 207Ifosfamide 208Imatinib 209Iohexol 210Ipratropium Bromide 212Irinotecan 214Isoflurane 217Isoniazid 218Isosorbide Dinitrate 219Itraconazole 219Ivermectin 223K 226Ketamine 226L 227Lactulose 227Lamivudine 228Lamotrigine 229Latanoprost 230Ledipasvir 235Leuprorelin 239Levamisole 241Levofloxacin 242Levonorgestrel 244Levothyroxine 247Lidocaine 248Linezolid 249Loperamide 251Lopinavir 252Loratidine 255Lorazepam 257Losartan Potassium 259Lumefantrine 261M 263Mannitol 263Mebendazole 264Medroxyprogesterone Acetate 265Mefloquine 269Meglumine Iotroxate 270Melarsoprol 271Mercaptopurine 272Meropenem 274Mesna 278Metformin 279Methadone 279Methotrexate 280Methyldopa 282Methylprednisolone 283Methylthioninium Chloride 288Metoclopramide 289Metronidazole 290Miconazole 291Midazolam 292Mifepristone 295Miltefosine 298Misoprostol 299Moxifloxacin 302N 305Naloxone 305Neostigmine Methylsulfate 306Nevirapine 307Niclosamide 309Nicotinamide 309Nifedipine 310Nifurtimox 310Nilotinib 311Nitrofurantoin 313Norethisterone and Norethisterone Enanate 314O 317Ofloxacin 317Ombitasvir 319Omeprazole 320Ondansetron 322Oseltamivir 323Oxamniquine 325Oxytocin 327P 330Paclitaxel 330Paracetamol 333Paritaprevir 334Penicillamine 339Pentamidine 340Permethrin 341Phenobarbital 342Phenytoin 343Piperacillin 344Piperaquine 346Praziquantel 347Prednisolone 349Primaquine 350Procarbazine 352Progesterone 353Proguanil 356Propofol 356Propranolol 357Propylthiouracil 358Prostaglandin E1 359Prostaglandin E2 362Pyrantel 366Pyrazinamide 367Pyridoxine 367Pyridostigmine Bromide 369Pyrimethamine 369Pyronaridine 370R 373Raltegravir 373Ranitidine 376Retinoic Acid (All-trans) 377Retinol (Vitamin A1) 378Ribavirin 380Rifabutin 382Rifampicin 384Rifapentine 386Risperidone 389Ritonavir 390S 395Salbutamol 395Simeprevir 397Simvastatin 402Sodium Calcium Edetate 404Sofosbuvir 405Spironolactone 408Succimer 410Sulfadiazine and Silver Sulfadiazine 411Sulfadoxine 412Sulfamethoxazole 413Sulfasalazine 415Suramin 416Suxamethonium Chloride 418T 419Tamoxifen 419Tazobactam 421Tenofovir Disoproxil 423Terbinafine 424Testosterone 425Tetracaine 427Tetracycline 428Thiamine 428Tigecycline 430Timolol 434Tranexamic Acid 435Triclabendazole 436Trimethoprim 437Tropicamide 438U 440Ulipristal Acetate 440V 445Valganciclovir 445Valproic Acid 447Vecuronium Bromide 448Velpatasvir 452Verapamil 459Vincristine 460Vinorelbine 461Voriconazole 463W 466Warfarin 466X 467Xylometazoline 467Z 469Zidovudine 469Zoledronic Acid 471A Demonstration: Amiodarone 472Index 478

O autorze

Peter J. Harrington, PhD, is the owner and primary consultant for Better Pharma Processes LLC, Boulder, Colorado, USA. Dr. Harrington is a pharmaceutical process design and development expert with more than twenty years' experience in timely process innovation for major pharmaceuticals. His publications include a book on pharmaceutical process chemistry for synthesis and several articles on organic and medicinal chemistry.