Structural Genomics and High Throughput Structural Biology

ISBN-13: 9780824753351 / Angielski / Twarda / 2005 / 304 str.

Michael Sundstrom; Aled Edwards; Martin Norin

Opis

Structural Proteomics provides a comprehensive overview of the field, covering basic discovery through practical applications. The book comprises the works of leading international experts and details state-of-the-art computational and analytical methods used to reveal the three-dimensional structure of proteins. This structure is used to determine the function of these proteins within cells. Assembled by a leader from the Structural Genomics Consortium at Oxford University, one of the largest research efforts in the world, this book disseminates the extensive practical experience of the authors and editor to structural, computational, medicinal, and analytical chemists and biologists.

Spis treści

Overview of Structural Genomics: Landscape, Premises, and Current Direction. Purifying Protein for Structural Biology. Protein Crystallization: Automation, Robotization and Miniaturization. NMR Spectroscopy in Structural Genomics. High Throughput Protein Crystallography. From Sequence to Function. Comparative Modeling and Structural Proteomics. Ab Initio Modeling. Determining Function from Structure. Retrieval and Validation of Structural Information. Problems in Computational Structural Proteomics. Therapeutically-Driven Structural Genomics.

O autorze

Michael Sundström, Martin Norin, Aled Edwards