Advances in Drug Discovery Techniques

ISBN-13: 9780471975090 / Angielski / Twarda / 1998 / 222 str.

Alan L. Harvey; Alan L. Harvey

Opis

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Spis treści

Sense, Nonsense and Antisense: Different Approaches to Drug Discovery (A. Harvey).

Natural Products for Durg Discovery: An Overview (P. Waterman).

Advanced Screening Technology and Informatics for Natural Products Drug Discovery (D. Hill).

Discovery of Specific Tyrosine Kinase Inhibitors from Microbial and Botanical Sources (G. McMahon, et al.).

Plant Cell Culture: A Vehicle for Drug Discovery (A. Stafford, et al.).

Pharmacy of the Deep –
Marine Organisms as Sources of Anticancer Agents (M. Jaspars).

Drug Discovery by Using Molecular Biology to Reprogramme Microorganisms (I. Hunter).

Small Molecule Drug Screening Based on Surface Plasmon Resonance (S. Kumar & K. Gunnarsson).

An Overview of Combinatorial Chemistry and Its Applications to the Identification of Matric Metalloproteinase Inhibitors (MMPIs) (S. Shuttleworth).

New Methods for Structure–based De Novo Drug Design (B. Waszkowycz).

Current and Future Capabilities in Automated Drug Screening and Development (I. Norrington).

Antisense Oligonucleotide Therapeutics (C. Bennett, et al.).

Index.

Blurb

This invaluable volume serves as a guide to up–to–the–minute techniques for the discovery and evaluation of pharmacologically active compounds for therapeutic development. Focusing on practical applications, provided by expert practitioners from both industry and academic research laboratories, Advances in Drug Discovery Techniques covers rational drug design, high–throughput screening and genetic approaches to drug discovery. Moreover, chapters also focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. Typical screening studies and their link to robotics and informatics are also presented in detail, together with an overview of current progress within antisense therapeutics. Overall, this book will be an excellent reference source for all individuals interested in making sense of the rapid changes in drug discovery that result from developments in molecular biology, robotics and informatics.