Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

ISBN-13: 9780470041468 / Angielski / Twarda / 2008 / 272 str.

Sheng Ding

Opis

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

Spis treści

Chapter 1. Embryonic Stem Cells (Crystal L. Sengstaken, Eric N. Schulze and Qi–Long Ying).

Chapter 2. Adult Stem Cells (Lief Fenno and Chad A. Cowan).

Chapter 3. Genome–wide expression analysis technologies (John R. Walker).

Chapter 4. Genomic cDNA and RNAi Functional Profiling and its Potential Application to the Study of Mammalian Stem Cells (Jia Zhang, Myleen Medina, Genevieve Welch, Deanna Shumate, Anthony Marelli, and Anthony P. Orth).

Chapter 5. Chemical Technologies: Probing Biology with Small Molecules (Nicolas Winssinger, Zbigniew Pianowski, and Sofia Barluenga).

Chapter 6. Protein Characterization by Biological Mass Spectrometry (Venkateshwar Reddy and Eric C. Peters).

Chapter 7. Large scale genomic analysis of stem cell populations (Jonathan D. Chesnut and Mahendra S. Rao).

Chapter 8. Exploring stem cell biology with small molecules and functional genomics (Julie Clark, Yue Xu, Simon Hilcove, and Sheng Ding).

Chapter 9. Regeneration Screens in Model Organisms (Chetana Sachidanandan and Randall T Peterson).

Chapter 10. Proteomics in stem cells (Qiang Tian and W. Andy Tao).

O autorze

Sheng Ding is an Associate Professor in the Departments of Chemistry and Cell Biology at the Scripps Research Institute. He is a member of the American Chemical Society, American Society for Cell Biology, and the International Society for Stem Cell Research. Dr. Ding is the author or coauthor of thirty–four papers and seventeen reviews and book chapters, in addition to being coholder of thirteen?patents.

Blurb

Promising technologies for exploring stem cells

Scientists believe that stem cells have the potential to repair specific tissues and to grow organs, revolutionizing the treatment of cardiovascular disease, neurodegenerative disease, musculoskeletal disease, diabetes, and cancer. A core reference for researchers, Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine consolidates the latest information on functional genomics and chemical biology approaches that are used to study and control the fate of stem cells. It discusses new technologies and their recent applications in various areas of stem cell biology, covering:

• The use of both embryonic and adult stem cells

• A vast array of technologies, including: genome–wide expression analysis, functional genomic profiling with arrayed cDNA and RNAi expression libraries, informatics, chemical genomics, mass spectrometry, and proteomics

• The applications of advanced technologies in various areas of stem cell biology, encompassing: self–renewal, differentiation, and reprogramming of different types of embryonic and adult stem cells, as well as regeneration in model organisms

• Technological tools for studying the biology of stem cells

With chapters contributed by leading authorities, this book is a hands–on reference for chemists, biologists, biochemists, bioinformaticians, clinicians, and managers involved in stem cell research. It is also an excellent text for interdisciplinary courses such as functional genomics, stem cell biology, and chemical biology.