Free Radicals in Biology and Medicine

ISBN-13: 9780198717485 / Angielski / Miękka / 2015 / 944 str.

Barry Halliwell; John M. C. Gutteridge

Opis

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing.
This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Recenzje

The content of Free Radicals in Biology and Medicine is as wide as the horizon and as deep as the ocean: nobody can ever dream to satisfactorily capture it in the limited space available for a book review. The target audience that will undoubtedly profit from this gigantic work is equally wide: biologists, biochemists, medical doctors, nutritionists, therapists with a sound background. It stands as an invaluable reference to be consulted without moderation, although a deep understanding certainly requires repeated reading and study.