Biochemistry of Lipids, Lipoproteins and Membranes

ISBN-13: 9780128240489 / Angielski

Neale Ridgway (Departments of Pediatrics;Roger McLeod (Department of Biochemistry

Opis

Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

Spis treści

1. Functional roles of lipids in biological membranes
Mikhail Bogdanov and William Dowhan
2. Methods of lipid analysis
Bebiana C. Sousa, Michael J.O. Wakelam and Andrea F. Lopez-Clavijo
3. Fatty acid and phospholipid biosynthesis in prokaryotes
Jessica M. Gullett and Charles O. Rock
4. Lipid metabolism in plants
Katherine M. Schmid
5. Fatty acid handling in mammalian cells
Richard Lehner and Ariel D. Quiroga
6. Fatty acid desaturation and elongation in mammals
Lucas M. O'Neill, Makoto Miyazaki, Laura M. Bond, Sarah A. Lewis, Fang Ding, Zhaojin Liu and James M. Ntambi
7. Phospholipid synthesis in mammalian cells
Neale Ridgway
8. Phospholipid catabolism
Dakai Zhang and Guangwei Du
9. Sphingolipids
Anthony H. Futerman
10. Cholesterol synthesis
Andrew J. Brown, Hudson W. Coates and Laura J. Sharpe
11. Structure and function of lipid droplets
Hongyuan Yang and Jun Liu
12. Bile acid metabolism
Jennifer K. Truong and Paul A. Dawson
13. Lipid modification of proteins
Marilyn D. Resh
14. Inter- and intra-membrane lipid transport
Vesa M. Olkkonen and Elina Ikonen
15. High-density lipoproteins metabolism and protective roles
Valentin Blanchard and Gordon A. Francis
16. Assembly and secretion of triglyceride-rich lipoproteins
Eric A. Fisher and Roger S. McLeod
17. Lipoprotein(a)
Michael B. Boffa and Marlys L. Koschinsky
18. Lipoprotein receptors
Kristina Kuhbandner, Joachim Herz and Theresa Pohlkamp
19. Atherosclerosis
Murray W. Huff and Katey J. Rayner
20. Diabetic dyslipidaemia
Khosrow Adeli, Changting Xiao, Victoria Higgins, Jennifer Taher, Sarah Farr and Gary F. Lewis

O autorze

Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body - cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer's, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements. Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body - and how different fats can either lead to, or prevent, chronic disease. He's particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.