Breathborne Biomarkers and the Human Volatilome

ISBN-13: 9780128199671 / Angielski / Miękka / 2020 / 670 str.

Cristina Davis; Jonathan Beauchamp; Joachim Pleil

Spis treści

• Foreword
• Dedication
• Preface

PART A: Concepts and modeling 1. Breath biomakers and the exposome 2. Breath sampling and standardization 3. Physiological modeling of exhaled compounds 4. Exhaled nitric oxide physiology and modeling

PART B: Inorganics and non-volatiles 5. Exhaled nitric oxide in clinical practice 6. Exhaled carbon monoxide 7. Exhaled breath condensate and aerosol 8. Exhaled particles

PART C: Analytics 9. Selected ion flow tube mass spectrometry 10. Proton transfer reaction-mass spectrometry 11. Ion mobility spectrometry 12. Secondary electrospray ionization 13. Sensor systems 14. Optical spectroscopy 15. Comprehensive gas chromatography-mass spectrometry 16. High-resolution mass spectrometry

PART D: Breath tests 17. 13C breath tests 18. Breath monitoring in the intensive care unit 19. Chronic obstructive pulmonary disease and smokers 20. Clinical phenotyping 21.  Breath analysis for respiratory infections 22. Volatile biomarkers of malaria infection 23. Lifestyle applications

PART E: Beyond human breath 24. Biomarkers in urine and stool 25. Volatile emissions from skin 26. Cell cultures as in vitro models for breath research 27. Ruminants 28. Breath analysis in marine mammals

PART F: Field applications 29.  Breath analysis in law enforcement 30. Drugs in breath 31. Urban search and rescue 32. Breath analysis in occupational medicine 33. Breath biomarkers in human xenobiotic exposure studies 34. Canine olfaction

PART G: Design and interpretation 35. Clinical study design 36. Challenges in clinical breath research development 37. Mathematical interpretation of targeted volatilome data 38. Preprocessing and analysis of volatilome data 39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research