Schizophrenia: Methods and Protocols

ISBN-13: 9781071633069 / Angielski

Leyre Urigüen; Rebeca Díez-Alarcia

Spis treści

1. A Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator. Focus on muscarinic M1 receptors

Geoffrey Pavey, Megan Snelleksz, and Brian Dean

 

1. Enhanced bystander BRET (ebBRET) biosensors as biophysical tools to map the signaling profile of neuropsychiatric drugs targeting GPCRs

Supriya A. Gaitonde and Michel Bouvier

 

1. [³⁵S]GTPγS (Guanosine-5′-O-(γ-thio)triphosphate-[³⁵S]) Binding Scintillation Proximity Assay experiments in postmortem brain tissue

I Muneta-Arrate and R Diez-Alarcia

 

CRISPR/Cas9 as a simple technique for the generation of murine knockout models for neuropsychiatric diseases

Lide Totorikaguena and Estibaliz Olabarrieta

 

1. Evaluation of sensory-motor gating deficits in mice through prepulse inhibition (PPI) of the startle response

Paula Unzueta-Larrinaga and Leyre Urigüen

 

Automated detection of psychedelic-induced head twitch response in mice

Alaina M. Jaster and Javier González-Maeso

 

Gastrointestinal and microbiome profiling in rodent models of neurological and psychiatric disorders

Geraldine Kong, Carolina Gubert, and Anthony J.  Hannan

 

1. Electroencephalography for the study of the auditory P300 evoked potential and derived measurements

Rosa M. Beño-Ruiz-de-la-Sierra; Inés Fernández-Linsenbarth, Alejandro Roig-Herrero, and Álvaro Díez-Revuelta

 

Quantification of endocannabinoids in human plasma

Aitor Villate, Markel San Nicolas, Oier Aizpurua-Olaizola, Maitane Olivares, Aresatz Usobiaga, and Nestor Etxebarria

 

1. Neuropsychological and functional assessment of cognitive impairments in schizophrenia

María Recio-Barbero, Noemi Losada León, Oihane Mentxaka, Janire Cabezas-Garduño, and Rafael Segarra

1. Clinical management and assessment of the early stages of psychosis: a multidimensional approach

Oihane Mentxaka Solozabal, María Recio Barbero, Janire Cabezas-Garduño, and  Rafael Segarra

Blurb

This volumes presents current methods used in the research of schizophrenia. Chapters guide readers through molecular techniques, in vivo approaches, cell cultures and heterologous expression systems, and even research methods involving human studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Schizophrenia: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.