Pharmacokinetics: Basics to Applications

ISBN-13: 9789811689529 / Angielski / Miękka / 2023 / 334 str.

Biswajit Mukherjee

Opis

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Spis treści

Chapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3:  The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4:  Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.

O autorze

Biswajit Mukherjee, Ph.D., W.B.C.S., F.I.C., F.I.C.S., is Professor in Pharmaceutics and former Head, in the Department, the Department of Pharmaceutical Technology, Jadavpur University, Kolkata and a former faculty of the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh. He was a DAAD (German Academic Exchange Services) Fellow and Guest Scientist, German Cancer Research Center (DKFZ), Heidelberg. He was a visiting fellow of the School of Pharmacy, University of London, and an Indo-Hungarian Education Exchange Fellow, of the National Research Institute for Radiobiology  Radiohygiene, Budapest. He works on Antisense Technology, cancer chemoprevention, drug nanocarriers, nanomedicine and targeted drug delivery systems, with a special focus on biopharmaceutics, pharmacokinetics and pharmacodynamic studies. He is the executive secretary of Indian Association of Pharmaceutical Scientists and Technologists. He is the recipient of Oversees Biotechnology Research Associateship 2005 (Department of Biotechnology, Govt. of India), University Grants Commission (India) research award 2009, and Association of Pharmaceutical Teachers of India -Professor C.J Shisoo award in 2016 for research in Pharmaceutical Sciences.