Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

ISBN-13: 9780123919182 / Angielski / Twarda / 2013 / 496 str.

Yui Wing Francis Lam

Opis

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

• Multi-contributed book and chapters are written by contributors who are experts in their field
• Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be
• Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications
• Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Recenzje

"...a practical and indispensable resource on both the opportunities and challenges that allows readers to reflect on the future direction of pharmacogenomics while applying these observations to their own work or research."--Anticancer Research, February 2015

"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."--Reference and Research Book News, August 2013

"This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine."--Doody.com, August 2, 2013

".this latest state-of-the-art book on pharmacogenomics successfully tackles the objectives described by its title. The key feature of the book is the in-depth discussion on a range of challenges currently facing pharmacogenomics in the widely publicised revolution in drug therapy. the Editors and the contributors are to be congratulated for their offering and this excellent book should serve well the needs of all those interested in the potential role of pharmacogenomic revolution in personalizing therapy." - British Journal of Clinical Pharmacology, November 5, 2013

Spis treści

SECTION 1

1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2 Translating Pharmacogenomic Research to Therapeutic Potentials 3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)

Section 2

4a Pharmacogenomics in Cancer Therapeutics 4b A Look to the Future:  Cancer epigenetics 5a Pharmacogenomics in Cardiovascular Diseases 5b A Look to the Future: Cardiovascular Pharmaco-epigenetics 6a Pharmacogenomics in Psychiatry Disorders 6b A Look to the Future: Epigenetics in psychiatric disorders and treatment 7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas 

SECTION 3

8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 9a Incorporating Pharmacogenomics in Drug Development Part 1:  Rational  study designs for pharmacogenetic research and therapy - A perspective  from academia 9b Incorporating Pharmacogenomics in Drug Development Part 2:  A perspective from industry 10 Ethnobridging and Pharmacogenomics

SECTION 4

11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine 12 The Economics of Pharmacogenomics

SECTION 5

13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough