New Therapies to Prevent or Cure Auditory Disorders

ISBN-13: 9783030404123 / Angielski / Twarda / 2020 / 186 str.

Sylvie Pucheu; Kelly E. Radziwon; Richard Salvi

Spis treści

1. Life-style intervention to prevent age-related hearing loss : calorie restriction 

 

1. Noise-induced hearing loss and drug therapy ; basic and translational science.

 

1. Review of ototoxic drugs and treatment strategies for reducing hearing loss.

 

1. Approaches to regenerate hair cells and spiral ganglion neuron in the inner ear. 

 

1. Immune system and macrophage activation in the cochlea: implication for therapeutic intervention

 

1. Preclinical animal Behavioral models of hyperacusis and Loudness recruitment

 

1. New automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models

O autorze

Dr. Sylvie Pucheu has more than 23 years' experience in academic research and the pharmaceutical industry. Dr. Pucheu is a founder and Chief Scientific Officer at CILcare, a preclinical provider in otology. Before co-founding CILcare, she led an in-vivo pharmacology group working on tinnitus and hearing loss. She has also led scientific teams at Sanofi, and has been involved in their Ethics Committee. 

Dr. Kelly E. Radziwon is a Research Assistant Professor in the Dept. of Communication Disorders and Sciences at the University of Buffalo and a member of Center for Hearing and Deafness. Her research focuses on the perceptual aspects of normal and impaired hearing in animal models.  Dr. Radziwon is an expert on tinnitus, hyperacusis, temporal processing deficits and complex auditory perception.

Dr. Richard Salvi is the co-founder and director of the University of Buffalo's Center for Hearing and Deafness. His lab focuses on multiple areas in the field of hearing and deafness. Dr. Salvi is an expert on the plasticity of the central auditory system, the effect of sensory hair cell loss on auditory function, noise-induced hearing loss, tinnitus, hyperacusis and auditory perception.

Blurb

This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells’ capacity to regenerate appears “repressed” in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.