miR-615-5p and miR-155-5p in Hepatocellular Carcinoma Immunotherapy: : A Couple of microRNAs and Four Faces in Natural Killer Cells and Their Target Hepatocytes in HCC

ISBN-13: 9783659823695 / Angielski / Miękka / 2016 / 132 str.

Mai Atef Rahmoon; Rana Ahmed Youness; Ahmed Ihab Abdelaziz

Opis

Stemming the rising tide of global ill health from liver disorders, hepatologists worldwide have never been challenged as such. Hepatocellular carcinoma (HCC) poses a heavy burden globally, pivoting on the geographic region, in Egypt; HCC ranks the second most prevalent cancer and the second most frequent cause of cancer related mortality. Yet, compelling the need to understand the pathogenesis of HCC. Despite being considered a main target in efforts directed towards drug development for HCC, the driving motto in the pathogenesis of HCC, IGF/IGF-IR pathway, has recently been cast in the homeostatic regulation of immunity. Provokingly, in my master thesis, I focused on immunotherapy utilizing NK cells to provide new insights in eradicating HCC and reconcile the challenge. Accordingly, miR-615-5p and miR-155 were chosen for such trial, paving the road for correction of NK functional impairment ex-vivo through IGF-axis manipulation and future perfusion of the cytotoxic NKs to HCC patients . Part of this work was presented in the Liver Meeting (AASLD), San Francisco 2015 and in the EASL international liver Congress Vienna 2015 and ranked from the top 10% e-posters in the convention.

O autorze

I graduated from German University in Cairo, Faculty of Pharmacy & Biotechnology in 2013, then I pursed my ultimate passion in Academics & science. In 2015, I defended my master and earned a degree in Molecular Medicine and Liver Pathology supervised by Prof. Dr. Ahmed Ihab and Dr. Hend Eltayebi.I work as an assistant lecturer & I am a PhD student.