This volume offers an up-to-date overview of essential concepts and modern approaches to computational modelling, including the use of experimental techniques related to or directly inspired by them. The book introduces, at increasing levels of complexity and with the non-specialist in mind, state-of-the-art topics ranging from single-cell and molecular descriptions to circuits and networks.

Four major themes are covered, including subcellular modelling of ion channels and signalling pathways at the molecular level, single-cell modelling at different levels of spatial complexity,...

More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs).

This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted...

This book delves into the intricate relationship between alcohol and the brain across different stages of life, offering groundbreaking insights from preclinical and clinical studies. From prenatal development to the complexities of aging, it unravels how alcohol interacts with neural networks, neurotransmitters, and cellular processes that govern behavior.

Starting with the prenatal period, the book will explore the effects of alcohol on the developing brain, shedding light on the potential cognitive and behavioral consequences that may persist into adulthood. It unravels the...