Kategoria BISAC: Science >> Life Sciences - Virology

This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also...

This book provides up-to-date information on the molecular diagnosis of viral diseases, including COVID-19, zika virus, human immunodeficiency virus (HIV), viral hepatitis, meningitis, and human papilloma virus (HPV). It covers global trends, the impact of viruses on society, and the need for molecular diagnostics. Initial chapters include information on popular molecular diagnostic methods and up-to-date strategies like Nucleic Acid Testing (NAT) and immunological methods, with an understanding of the challenges in their development. Further chapters emphasize emerging and next-generation...

This detailed new edition collects state-of-the-art methods in the fields of hepatitis B virus (HBV) molecular biology and immunology. The book features techniques for cell culture, epigenetic regulation of cccDNA transcription, epitranscriptomic modification of HBV RNA, HBV pregenomic RNA and subviral particle morphogenesis, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and...

This volume looks at the latest techniques used in the study of Rift Valley Fever Virus (RVFV). The chapters in this book cover topics such as molecular biology, biochemistry, and cell biology approaches that enable the mechanistic study of virus-host interactions; vector competence, detection, and diagnosis; virus inactivation for biosafety purposes; virus and protein production for structural studies; high-throughput screening based on CRISPR-Cas9 technology; single-molecule RNA imaging; and physiological infection models, animal models, and immunology. Written in the high successful...

This book provides an overview of the science and technology that helps us understand the trajectory, i.e., genomics, epidemiology, and health care of the COVID-19 pandemic, its virus, and pathogenicity. Topics that are covered include how the virus is impacting our health care system and the economy. Simulation modeling used to predict the spread of the virus and risk of infection in America and globally is included, as well as the critical role of communication in pandemic response.

An important focus is synthetic biology, notably employed in the development and production of...

Latin America has extensive microbial diversity and is endemic for a wide array of infectious agents including dengue, chikungunya, malaria and tuberculosis. In 2014, the WHO cited 93 public health events of potential international concern in the Latin American region where over half (47 events) were caused specifically by chikungunya and other zoonotic pathogens, causing geographically widespread impact affecting 27 countries and territories. Arena, alpha and flaviviruses are RNA viruses, many of which are endemic in South America, are diverse in nature, and can adapt easily to new hosts,...