Kategoria BISAC: Science >> Research & Methodology

Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter,...

This fully updated edition explores current techniques for research into antibiotic resistance. The book begins with how samples are collected, strains isolated and sequenced, and the results integrated in the microbiological workflow.  It continues with novel methods to test resistance and interactions between antibiotics, physiological conditions, or using innovative tools like the hollow fiber or Raman spectroscopy, as well as mathematical models that can describe resistance within host. Written for the highly successful Methods in Molecular Biology series,...

This detailed new edition explores current methods for the production and use of peptide antibodies. The book delves into various aspects of peptide synthesis and analysis, peptide-carrier conjugation, epitope and paratope prediction and identification, as well as improved assays and other uses of peptide antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective chapters, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting...

In recent years, extensive research on stochastic processes such as neuron networks, molecular motors, dynamics models, anomalous diffusion, and disordered media has led to the development of various methods for applying the Classical and Quantum Smoluchowski Equation to these phenomena. This book focuses on presenting the solution to the Fokker-Planck equation using the Crank-Nicholson formalism. This method is particularly effective for handling systems with numerous interactions, requiring vector and matrix-oriented approaches suitable for implementation in Matlab. Among the topics...

This volume details in methods to assess memory B cell formation and function in mice and humans. Chapters guide readers through tetramer-based methods to assess antigen-specific memory B cell dynamics in humans and mice in different vaccine, next-generation deep-sequencing, single-cell techniques to assess epigenomic, VDJ landscapes, lymph node aspirates from humans, advanced imaging, murine models to determine memory B cells formation, and bioinformatic techniques and in silico modelling of memory b cell formation. Written in the highly successful Methods in Molecular Biology...

This book focuses on the various invasive and non-invasive techniques which can be used for the characterization of starch macromolecules along with, the various types of physical, chemical, and enzymatic modifications of starch to enhance its usage in the food industry. It discusses various biophysical techniques, including scanning electron microscopy, Fourier transforms infrared spectroscopy, X-ray diffraction, Raman scattering, and second harmonic generation microscopy for the understanding of the Physico-chemical properties of starch. The book also sheds light on the visual,...

Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of...