Kategoria BISAC: Science >> Research & Methodology

With the ultimate goal of systematically and robustly defining the specific perturbations necessary to alter a cellular phenotype, systems metabolic engineering has the potential to lead to a complete cell model capable of simulating cell and metabolic function as well as predicting phenotypic response to changes in media, gene knockouts/overexpressions, or the incorporation of heterologous pathways. In Systems Metabolic Engineering: Methods and Protocols, experts in the field describe the methodologies and approaches in the area of systems metabolic engineering and provide a...

• At least 50% new information than first edition
• Includes topics on rat genetics and...

Over the past decade, the author has met with directors of R&D departments in large industrial firms, who are frustrated by the lack of coherent and consistent methodologies in R&D projects. As a direct result the author was asked to design and present a seminar to provide R&D engineers and scientists a standard methodology for conducting coherent, rigorous, comprehensible, and consistent R&D projects. The author also realized that this training should be included in engineering and science curricula in universities and colleges. To this end, he designed and presented a pilot course for...

"Crease's brilliantly exploited theatrical analogy places scientific theorizing back into the wider context of experimental inquiry." --Robert C. Scharff

Crease attacks the "mystical" account of experimentation embraced by the positivist and Kantian varieties of philosophy of science, according to which experimentation takes a backseat to theory.

Santiago Ramon y Cajal was a mythic figure in science. Hailed as the father of modern anatomy and neurobiology, he was largely responsible for the modern conception of the brain. His groundbreaking works were New Ideas on the Structure of the Nervous System and H istology of the Nervous System in Man and Vertebrates. In addition to leaving a legacy of unparalleled scientific research, Cajal sought to educate the novice scientist about how science was done and how he thought it should be done. This recently rediscovered classic, first published in 1897, is an anecdotal guide...

Wagman offers a critical analysis of current theory and research in the psychological and computational sciences, directed toward the elucidation of scientific discovery processes and structures. It discusses human scientific discovery processes, analyzes computer scientific discovery processes, and makes a comparative evaluation of the two. This work examines the scientific reasoning of the discoverers of the inhibition mechanism of gene control; scientific discovery heuristics used at different developmental levels; artificial intelligence and mathematical discovery; the ECHO system; the...