Kategoria BISAC: Science >> Life Sciences - Human Anatomy & Physiology

The gene, and its protein product, in a serious inherited muscle disease was first identified in the case of Duchenne muscular dystrophy some twenty years ago. Dystrophin turned out to be a sarcolemmal protein. This was somewhat of a surprise because many had harboured the view up until then that most muscle diseases, if not all, might be due to defects in the sarcomere itself. After all this was the site of muscle contraction. However many other muscular dystrophies have subsequently been shown to be due to defects in various other sarcolemma-associated proteins.¹

The...

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for...

The major goal of developmental neurobiology is to understand how the nervous system is put together. A central theme that has emerged from research in this field over the last several decades is the crucial role of trophic interactions in neural assembly, and indeed throughout an animal's life. Trophic--which means nutritive--refers to long-term interdependencies between nerve cells and the cells they innervate.

The theory of trophic effects presented in this book offers an explanation of how the vertebrate nervous system is related to--and regulated by--the body it serves. The...

Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the...

This is the only book entirely devoted to the sensory circumventricular organs. It reviews research into their detailed anatomy, neurochemistry, neural connections, and functions, and provides the reader with many illustrations previously unpublished.

This volume summarizes the state of development of auditory system neuroscience. This field is in an era of remarkable progress, particularly in the field of plasticity of the auditory system. New advances in understanding auditory system plasticity, based substantially on a large and growing body of results from animal experiments, are related to innumerable new insights into the physiology and pathology of speech and music perception and production generated by behavioral studies, and from the application of modern brain imaging techniques. We are living in an especially exciting period...

International Research in Science and Soccer showcases the very latest research into the world's most widely played sport. With contributions from world-leading researchers and practitioners working at every level of the game, from grass roots to elite level, the book covers every key aspect of preparation and performance, including:

• contemporary issues in soccer coaching
• psychological preparation and development of players
• physical preparation and development of players
• nutrition and recovery
...

The subject of the book is the grounding of architectural acoustics in psychophysics (perception, listener preferences) and neuroscience (auditory function, neural correlates of perception and preference). This is the first rational-scientific approach to designing performance spaces that is based on systematic psychoacoustical observations of spatial hearing and listener preferences. Observations of the neuronal correlates of auditory qualities and listener preferences ground the theory of listener preferences in the neurophysiology of the human brain. A correlation-based model of...