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Transcriptional Control of Cell Growth: The E2f Gene Family
ISBN: 9783642799129 / Angielski / Miękka / 141 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through- out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor- mally control this decision can lead to cancer, cell death, or loss of...
It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through- out the lifespan of a...
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407,25 |
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Molecular Ecology of Aquatic Microbes
ISBN: 9783642799259 / Angielski / Miękka / 415 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book is concerned with new applications of molecular biology techniques to aquatic microbiology and demonstrates the potential to solve some intractable problems. It deals in depth with topics ranging from the ability of molecular techniques to characterize assemblages of microorganisms which cannot be cultured, to novel ways to measure rates of production. In addition to the chapters which emphasize the molecular approach, a number of contributions, written by eminent aquatic microbiologists, highlight important processes that are making rapid progress.
This book is concerned with new applications of molecular biology techniques to aquatic microbiology and demonstrates the potential to solve some intr...
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610,90 |
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Attempts to Understand Metastasis Formation III: Therapeutic Approaches for Metastasis Treatment
ISBN: 9783642800733 / Angielski / Miękka / 262 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas- tasis research and to attempt to further understand the biol- ogy of this multifocal process. With respect to present day...
In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis ...
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407,25 |
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Adeno-Associated Virus (Aav) Vectors in Gene Therapy
ISBN: 9783642802096 / Angielski / Miękka / 173 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se- quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type,...
Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the a...
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407,25 |
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Protein Modules in Signal Transduction
ISBN: 9783642804830 / Angielski / Miękka / 368 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The behavior of eukaryotic cells, particularly those of multicel lular organisms, depends on the transmission of signals from one cell to another. Such extracellular signals can take the form of hormones, antigens, cells surface molecules, or components of the extracellular matrix and exert their effects by binding to specific receptors, usually exposed on the surface of the target cell. These transmembrane receptors possess a cytoplasmic domain that al lows communication with intracellular signaling pathways, pro viding access to the regulation of gene expression, cytoskeletal architecture,...
The behavior of eukaryotic cells, particularly those of multicel lular organisms, depends on the transmission of signals from one cell to another. Suc...
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407,25 |
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Selective Heat Sensitivity of Cancer Cells
ISBN: 9783642810824 / Angielski / Miękka / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio- chemical lesion as well as at the optimization of technique and of the therapeutic...
Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bu...
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407,25 |
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Effects of Ionizing Radiation on DNA: Physical, Chemical and Biological Aspects
ISBN: 9783642811982 / Angielski / Miękka / 384 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This publication presents the culmination of collaborative effort between specialists in the wide range of disciplines concerned with the effects of ionizing radiations on nucleic acids. The authors belong to a group formed under the aegis of the Com mission of the European Communities some eight years ago with the object of facilitating the exchange of ideas and inforrration between European scientists working in this field. The Commission'S aim was not to replace traditional information channels, but to strengthen the various links between the scien tists in the group, as if they were...
This publication presents the culmination of collaborative effort between specialists in the wide range of disciplines concerned with the effects of i...
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407,25 |
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Biological Chemistry of Organelle Formation: 31. Colloquium, 14.-19. April
ISBN: 9783642815591 / Angielski / Miękka / 254 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Eukaryotic cells contain a plurality of organelles distinguished by their specific membranes and contents. Their biogenesis occurs by growth and division of preexisting structures rather than de novo. Mitochondria and chloroplasts, which appear to be descended from prokaryotic ancestors, have retained some DNA and the biosynthetic capability for its expression. They synthesize, however, only a few of their proteins themselves. Most of their proteins are synthesized on free ribosomes in the cytoplasm and are only assembled in the correct membrane after synthesis is complete. The biogenesis of...
Eukaryotic cells contain a plurality of organelles distinguished by their specific membranes and contents. Their biogenesis occurs by growth and divis...
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407,25 |
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Predictive Drug Testing on Human Tumor Cells
ISBN: 9783642822971 / Angielski / Miękka / 288 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity. The advantages of an effective test would lie in obviating the need for testing antineoplastic agents on large cohorts of patients for assessment of drug activity (phase II studies) and in allowing determination of optimal use of anticancer agents (phase III trials). Such an in vitro test could help to better define dose and schedule of drugs preclinically. The additive value of...
Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents a...
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407,25 |
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Adaptation to Altitude-Hypoxia in Vertebrates
ISBN: 9783642823183 / Angielski / Miękka / 176 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Adaptation to altitude hypoxia is characterized by a variety offunctional changes which collectively facilitate oxygen trans port from the ambient medium to the cells of the body. All of these changes can be seen at one time or another in the course of hypoxic exposure. Yet, as already stressed (Hannon and Vogel, 1977), an examination of the literature gives only a sketchy and often conflicting picture of the exact nature of these changes and how they interact as a function of exposure duration. This is partly because of the limited number of variables explored in a given study, but it is...
Adaptation to altitude hypoxia is characterized by a variety offunctional changes which collectively facilitate oxygen trans port from the ambient med...
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407,25 |
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Small Cell Lung Cancer
ISBN: 9783642823749 / Angielski / Miękka / 168 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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407,25 |
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Nucleic Acids and Molecular Biology
ISBN: 9783642833861 / Angielski / Miękka / 223 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable. With...
Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferati...
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541,33 |
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Ovarian Follicles in Reptiles and Birds
ISBN: 9783642836305 / Angielski / Miękka / 285 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In 1954, when I obtained my B. Sc. (Honours School) degree in Zoology, I was asked by my advisor, the late Professor Vishwa Nath, to make comparative cytological studies of oogenesis in birds for my M. Sc. (Honours School) thesis submitted to the Panjab University in 1956. Using the classical techniques of cytology, I studied the various aspects of follicle growth and atresia in five species of birds. Professor Vishwa Nath, who himself devoted most of his life to the study of the comparative cytology of gametogenesis in animals, was so much impressed by my findings on avian oogenesis that he...
In 1954, when I obtained my B. Sc. (Honours School) degree in Zoology, I was asked by my advisor, the late Professor Vishwa Nath, to make comparative ...
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541,33 |
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Cellular and Molecular Biology of Myelination
ISBN: 9783642839702 / Angielski / Miękka / 565 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Experts in the field of cellular and molecular biology of myelination present their latest results. Various techniques were used such as tissue culture, transplantation, transfection, immunocytochemistry and approaches to study the phylogenetic aspects of myelination as well as molec- ular biology. Concerning glial cells: hormones and second messengers play an important role in the regulation of the phenotype and the expression of myelin components at the transcriptional level; these findings are also part of particular relevance for remyelination. Concerning myelin: compositional studies...
Experts in the field of cellular and molecular biology of myelination present their latest results. Various techniques were used such as tissue cultur...
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cena:
610,90 |
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Genetic Improvement of Tomato
ISBN: 9783642842771 / Angielski / Miękka / 358 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The esculent Lycopersicon esculentum, long thought to be poisonous, has become a major U. S. food crop and source of vitamins and minerals, thanks largely to genetic modification and new production technology Rick (1978) Tomato (Lycopersicon esculentum Mill. ) is one of the most important solana ceous vegetable crops grown worldwide under outdoor and indoor conditions. It has become an important commercial crop so far as the area, production, industrial values and its contribution to human nutrition is concerned. During the past few decades tremendous developments have contributed to the...
The esculent Lycopersicon esculentum, long thought to be poisonous, has become a major U. S. food crop and source of vitamins and minerals, thanks lar...
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407,25 |
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Prader-Willi Syndrome: And Other Chromosome 15q Deletion Disorders
ISBN: 9783642842856 / Angielski / Miękka / 265 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Although Prader-Willi syndrome was first described 35 years ago, it was following detection of an interstitial chromosome 15q deletion in some affected patients ten years ago that it became a major focus of multidisciplinary scientific interest. This interest was compounded by the later determination that some patients with a clinically distinct disorder, Angelman syndrome, apparently also had the same chromosome 15q deletion. Subsequently, molecular genetic studies showed that some cytogenetically normal patients with both disorders have uniparental disomy, maternal in Prader-Willi syndrome...
Although Prader-Willi syndrome was first described 35 years ago, it was following detection of an interstitial chromosome 15q deletion in some affecte...
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570,17 |
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Neurocytochemical Methods
ISBN: 9783642843006 / Angielski / Miękka / 335 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The great strides made in the field of morphological methods during the past decades have perhaps found their most spectacular expression in the functional exploration of the nervous system. In comparison with other tissues, nerve tissue displays three kinds of specificity: structural, because of the unique organization of the neuronal networks; chemical as shown, for example, by the informative molecules exchanged between the nerve cells, and of course functional, thanks to the particular metabolic and electrophysiological characteristics of the neurons. Although for a long time the...
The great strides made in the field of morphological methods during the past decades have perhaps found their most spectacular expression in the funct...
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541,33 |
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Molecular Evolution of the Major Histocompatibility Complex
ISBN: 9783642846243 / Angielski / Miękka / 509 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a...
From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too,...
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cena:
814,55 |
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Scanning Microscopy: Symposium Proceedings
ISBN: 9783642848124 / Angielski / Miękka / 207 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. With the invention of the scanning tunneling microscope in 1982 by Binnig and Rohrer and the subsequent award of the Nobel Prize, the field of scan ning microscopy was given a strong boost in view of its wide range of ap plications. In particular, expanding the capability to access nature's foundations at the atomic level is now recognized as having the potential for major impact in Infonnation Technology. This third volume of the ESPRIT Basic Research Series provides a well structured overview of the state of the art of scanning microscopy and re cent advances including results of ESPRIT...
With the invention of the scanning tunneling microscope in 1982 by Binnig and Rohrer and the subsequent award of the Nobel Prize, the field of scan ni...
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cena:
407,25 |
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Lehrbuch Der Pflanzenphysiologie
ISBN: 9783642964541 / Niemiecki / Miękka / 619 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
cena:
209,31 |
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