New Aspects of Zirconium Containing Organic Compounds
ISBN: 9783642424151 / Angielski / Miękka / 175 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The most prominent metal carbenes are now either commercially available or easy to synthesize and handle with modern laboratory techniques. This volume organized in eight chapters written by the leading scientists in the field illustrates the theoretical background,... Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportun... |
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778,22 zł |
Fine Particles in Medicine and Pharmacy
ISBN: 9781489991270 / Angielski / Miękka / 348 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Pharmaceutical manufacture is very exacting - for example, drugs must be uniform in size, shape, efficacy, bioavailability, and safety. The presence of different polymorphs in drug production is a serious problem, since different polymorphs differ in bioavailability, solubility, dissolution rate, chemical and physical stability, melting point, color, filterability, density, and flow properties. Fine Particles in Medicine and Pharmacy discusses particle size, shape, and composition and how they determine the choice of polymorph of a drug.
Pharmaceutical manufacture is very exacting - for example, drugs must be uniform in size, shape, efficacy, bioavailability, and safety. The presence o...
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cena:
389,09 zł |
Drug Discovery for Schizophrenia
ISBN: 9781782620266 / Angielski / Twarda / 289 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from...
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, point...
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881,66 zł |
Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of Pac3 Homodimer
ISBN: 9784431554462 / Angielski / Twarda / 109 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein-protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique...
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein-protein interactions (PPIs) of proteasome assembling chaperone ...
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cena:
389,09 zł |
Kinesins and Cancer
ISBN: 9789401797313 / Angielski / Twarda / 271 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular... This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as pote... |
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cena:
389,09 zł |
Phosphorus Chemistry I: Asymmetric Synthesis and Bioactive Compounds
ISBN: 9783319154725 / Angielski / Twarda / 242 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future...
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most signific...
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cena:
778,22 zł |
Phosphorus Chemistry II: Synthetic Methods
ISBN: 9783319155111 / Angielski / Twarda / 277 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future...
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most signific...
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cena:
778,22 zł |
Modelling of Gpcrs: A Practical Handbook
ISBN: 9789401780919 / Angielski / Miękka / 218 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is - in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book "Modelling of GPCRs - a practical handbook" is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in... G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a larg... |
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583,65 zł |
Halogen Bonding II: Impact on Materials Chemistry and Life Sciences
ISBN: 9783319157313 / Angielski / Twarda / 208 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it...
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage i...
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1167,35 zł |
Prävention Kardiovaskulärer Erkrankungen Und Atherosklerose
ISBN: 9783658083588 / Niemiecki / Miękka / 32 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Inga Kuhlmann, Dawn Chin und Gerald Rimbach geben eine Einfuhrung zu Stickstoffmonoxid-Synthasen und deren Bedeutung in der Pravention und Pathogenese kardiovaskularer Erkrankungen. Auerdem liefern sie einen Uberblick zu Apolipoprotein E und dessen Bedeutung in der Entwicklung einer Atherosklerose. Die Autoren geben abschlieend Empfehlungen fur eine gesunde Ernahrung zur Pravention von Herz-Kreislauf-Erkrankungen.
Inga Kuhlmann, Dawn Chin und Gerald Rimbach geben eine Einfuhrung zu Stickstoffmonoxid-Synthasen und deren Bedeutung in der Pravention und Pathogenese...
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cena:
95,68 zł |
Enzyme: Teil C
ISBN: 9783662406953 / Niemiecki / Miękka / 998 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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181,80 zł |
Superstition in Medicine
ISBN: 9783737211291 / Angielski / Miękka / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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130,47 zł |
Ruthenium-Nhc-Katalysierte Asymmetrische Arenhydrierung: Entwicklung Neuer Effektiver Homogener Hydrierkatalysatoren
ISBN: 9783658089665 / Niemiecki / Miękka / 85 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Christoph Schlepphorst entwickelt ein rationales Ligandendesign fur die Ruthenium-NHC-katalysierte asymmetrische Hydrierung (hetero-)aromatischer Verbindungen. Zudem synthetisiert er eine Reihe von entsprechenden Carbenvorlaufern und charakterisiert diese. Die synthetisierten Carbenvorlaufer werden auerdem auf ihre Eignung als Liganden in Ru-NHC-katalysierten Hydrierreaktionen getestet. Der Autor optimiert bei diesem Vorgehen die asymmetrische Hydrierung ungeschutzter monosubstituierter Pyrazine im Hinblick auf die Reaktionsbedingungen und kann Enantiomerenverhaltnisse von bis zu 91:9 mit...
Christoph Schlepphorst entwickelt ein rationales Ligandendesign fur die Ruthenium-NHC-katalysierte asymmetrische Hydrierung (hetero-)aromatischer Verb...
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cena:
199,97 zł |
Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen Rm2 from Prostate Cancer
ISBN: 9783662468470 / Angielski / Twarda / 108 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the 1]2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1 10 to create the prostate cancer vaccine candidate, which is combined with -galactosylceramide C1, its analogue C34, or... This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents t... |
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cena:
194,52 zł |
Protein Ligation and Total Synthesis I
ISBN: 9783319191850 / Angielski / Twarda / 270 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole.
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole.
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cena:
778,22 zł |
Protein Ligation and Total Synthesis II
ISBN: 9783319191881 / Angielski / Twarda / 229 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future...
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most signific...
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cena:
778,22 zł |
Electrophoresis: Theory and Practice
ISBN: 9783110330717 / Angielski / Twarda / 871 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Electrophoresis is a straightforward but informative analytical method used in biochemistry, biology and medicine. This book combines a detailed discussion of theory and technical application with an elaborate section on troubleshooting and problem solving in electrophoresis. Therefore the book is an important guide for both students and scientists. Electrophoresis is a straightforward but informative analytical method used in biochemistry, biology and medicine. This book combines a detailed di... |
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cena:
1043,78 zł |
Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
ISBN: 9783658101602 / Angielski / Miękka / 153 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines;
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-...
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cena:
194,52 zł |
Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones
ISBN: 9783319205434 / Angielski / Twarda / 202 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the...
This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. First...
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cena:
389,09 zł |
Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols
ISBN: 9781493932511 / Angielski / Twarda / 272 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes to help laboratorians easily reproduce the protocols... This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topic... |
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cena:
389,09 zł |