Kategoria BISAC: Science >> Life Sciences - Biochemistry

The authoritative guide on protein purification--now completely updated and revised

Since the Second Edition of Protein Purification was published in 1998, the sequencing of the human genome and other developments in bioscience have dramatically changed the landscape of protein research. This new edition addresses these developments, featuring a wealth of new topics and several chapters rewritten from scratch.

Leading experts in the field cover all major biochemical separation methods for proteins in use today, providing professionals in biochemistry, organic...

Recent Advances in Polyphenol Research

Volume 2

Edited by Santos-Buelga, Escribano-Bailon and Lattanzio

Plant phenolics are secondary metabolites that constitute one of the most common and widespread groups of substances in plants. Polyphenols have a large and diverse array of beneficial effects on both plants and animals. For example they are famous as antioxidants, hormones, constituents of essential oils and natural neurotransmitters.

Sponsored by Groupe Polyphenols, this publication, which is the second volume in this ground-breaking series, is edited...

The field of plant nitrogen metabolism continues to be a compelling focus for basic research activities because there is a strong demand for immediate solutions, particularly in key areas, such as improving plant nitrogen use efficiency, which are crucial to future agricultural sustainability and the future economic success of agriculture.

The 13 reviews which comprise this excellent and carefully edited new volume bring together the expertise and enthusiasm of an international team of leading researchers. Topics covered include nitrogen sensing and signalling, uptake and membrane systems,...

Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.
A ready reference for...

Proteases or proteinases have a wide application in different industrial processes including cheese production, meat tenderization, production of protein hydrolysates, silver recovery and silk; in many other fields including biotechnological, baking, textiles, pharmaceutical and leather industries and also, as an additive to detergents and in bioremediation procedures. These enzymes are present in plants, animals and microorganisms (protozoa, bacteria, fungus and some types of algae and viruses). Considering the wide applications of these enzymes, it is necessary to know their functions,...

This book seeks to fill in the current technology gap with a specific collection of technologies developed for the study of protein function at a proteome scale. Chapters explore topics from protein functions to other aspects of protein analysis, especially in post-translational modification, as most proteomes use this mechanism in some capacity to carry out their unique role in cellular regulation. By comparing functional proteomes, this presents a bridge to other levels of system biology research including genomics and metabolomics in order to provide readers with a relatively complete...

Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension of classical protein chemistry, owing much of its maturation to prior contributions. Unfortunately, this debt is not always evident in current literature. The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application,...

This book explains the theoretical principles of numerous techniques of genomic studies developed recently in laboratories. The book is designed for any reader who is curious to know the bases of different techniques of manipulation of nucleic acids.

The knowledge of metal ion speciation is essential for predicting the exact toxicities of metal ion species in the environment. Metal ions can exist in various oxidation states, each of which possesses different physical and chemical properties as well as exhibit varying toxicities. Often, toxicity data is unreliable because it is based on metal ion concentration measurements that fail to identify a dominant species either more or less harmful than the average. Instrumental Methods in Metal Ion Speciation provides analytical techniques and experimental methodologies for determining the...

Written primarily for 16-19 year old students, this primer aims to extend students' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. This is a concise, stimulating...

Micronucleus is defined as the small nucleus that forms whenever a chromosome or its fragment is not incorporated into one of the daughter nuclei during cell division. It is concluded that micronucleus assay can be used for risk prediction, screening, diagnosis and treatment of various chronic diseases. In this Micronucleus Assay: An Overview, the applications of micronucleus assay will be discussed. Ionizating radiations, ultraviolet rays, geogenic or anthropogenic pollutants can induce mutagenic, teratogenic or carcinogenic effects due to the induction of micro or macrolession over DNA....

Adopting a novel approach to the topic that links the contents of both biosynthesis and chemical synthesis through mechanistic examination, this book provides a modern perspective on polyketides and non-ribosomal peptides. Following a general introduction to the field of natural products, the internationally recognized expert authors combine biosynthesis and enzymology with total synthesis strategies towards both compound classes. They also describe the mode of action for the most important polyketide and non-ribosomal peptide representatives. With its unique scope, this is an essential...

Angiotensin-converting enzyme (ACE) is a well-known zinc-metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and degrades bradykinin, a powerful vasodilator, both for the regulation of vascular tone and cardiac functions. Other natural substrates of ACE were identified broadening the functions of this enzyme within different physiological contexts such as neuronal metabolism, hematopoiesis, digestion, and reproduction. In this context, ACE has an essential role in diseases, for instance, hypertension, Alzheimers disease, oxidative stress, sperm maturation...

The book has been revised with addition of topics as per latest Medical Council of India (MCI) guidelines for undergraduate curriculum. Additional chapters like Lean Six Sigma Approach for Clinical Laboratories, Anemia Profile, Bone Markers, Components Associated with Research Work and its Publication, etc. have been added. This book will not only equip undergraduates with basic facts of the subject but will also help postgraduate studentston keep abreast with the latest knowledge. To bridge the gap between clinicians and clinical laboratories, more than 400 case reports and viva questions...

Advanced Glycation End-Products: Sources and Effects attempts to describe the role of advanced glycation end-products, particularly dietary advanced glycation end-products, in the pathological expansion of adipose tissue as well as their implications in the development of obesity associated complications. The effects of advanced glycation end-products on vasculature and their pathological implications are also described, focusing on the epigenetic mechanisms (particularly that of miRNA) modulating their effects. The authors summarize the information available on the impact of hyperglycemia on...

The present book encompasses and gives brief information about pyrophosphate materials. It also explains their phenomenological theories and properties of rare-earth activated pyrophosphates. This book provides the comprehensive in depth information about the development of phosphates and pyrophosphates along with their essential characterization techniques as well as their diversified applications in numerous domains. This book envelopes all essential information about single and mixed cations pyrophosphate compounds that have been used in past few years. It also covers intact information...

Histidine dipeptides and their derivatives have a significant role in a variety of physiological and pathological processes. Thus, the authors discuss the available analytical methods for the determination of various bioactive histidine dipeptides and their derivatives, their advantages and disadvantages, as well as their specific applications. The authors propose that the investigation of the structure of peptides is of fundamental importance as airst step to understanding their role in the mechanisms of the formation and biochemical functions of proteins. The biological activities of...

This book covered the current knowledge on structural as well as functional attributes of Heat shock protein 70 (Hsp70), which is the prime as well as abundant stressor protein in biological systems. In this book, the authors discuss research including the Heat Shock Proteins: History, Discoveries, and Implications in Diseases, Therapeutic and Research Options; Intracellular Versus Extracellular Hsp70; Role of Hsp70 in Sperm Quality; Heat Stress and Livestock Adaptation: An HSP70 Perspectives; Bovine Heat Shock Protein 70 (Hsp70) and Its Role In Thermoregulation; The Role of Hsp70 in Sperm...

In this compilation, the authors provide an overview of the various thermochemical routes for the conversion of triglycerides to biofuels, which mainly includes transesterification, thermal and catalytic cracking, and hydrodeoxygenation. Severe hypertriglyceridemia, defined as serum triglyceride levels more than 1000 mg/dL, is discussed in detail. This condition is a rare occurrence, but up to one fifth of this group with severe hypertriglyceridemia may develop acute hypertryglyceridemic pancreatitis. Available data is reviewed in an effort to evaluate the usefulness of the...