Kategoria BISAC: Medical >> Genetics

Today's cellular therapies enable individualized treatment for hematological diseases, inborn immunodeficiency, as well as other illnesses. Procedures for detecting specific cell populations play a critical role in diagnosis, the quality control of cell therapy products, and the evaluation of therapeutic success. For the first time, this book presents the latest scientific understanding of these procedures in context.

The aim of this volume is to provide a step-by-step guide for implementing a selection of novel techniques in the lab. Each protocol in this volume is presented as a standalone chapter, specifically geared towards addressing practical needs without presuming prior knowledge of the technique at hand. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known...

This book presents recent advances in translational research on muscular dystrophy (MD) to physicians and researchers, including cutting-edge research on the disease such as regenerative medicine, next-generation DNA sequencing, and nucleic acid therapies. It also describes the current systems for clinical trials and MD patient databases, resources, which will support the early realization of clinical application and improve patients quality of life.

MD is the one of the most widely known inherited neuromuscular diseases and is classified into diverse types by symptoms, age of onset,...

This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.

The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first...

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells...

This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today's initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling,...

Before Gordon Crozier was "Doctor" Gordon Crozier, he was chronically ill. He was so sick he couldn't crawl off the bed, so ill he could hardly eat, so cognitively impaired that for two years he lost the ability to read. He was desperate and his doctors literally gave up.

But there was a silver lining in his sickness; it led him to find answers in the study of integrative medicine and how a person's genetic make-up can ultimately bring healing. Dr. Crozier's own sickness became a pathway to healing for others.

In this groundbreaking book, you'll discover how Dr. Gordon...

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the...