Kategoria BISAC: Medical >> Research

Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the "true" endpoints of primary interest. Regulatory agencies around the globe,...

Experienced scientists and medical researchers know how important it is to engage with research literature in an active, critical and analytical way. However in most universities little time is devoted to teaching the relevant skills. Readers who accept scientific papers uncritically may misunderstand results, misinterpret the experimental significance of techniques, over or underestimate the importance of findings and waste time and resources on flawed or unnecessary experiments.
Critical Reading is aimed at everyone who needs to read original research...

Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006

Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced - and are being developed further - that facilitate monitoring of...

To help researchers take on this challenge, the book:

• highlights some of the choices involved in carrying out qualitative research
• offers a wide range of practical examples to show how different ways of doing...

Human Embryonic Stem Cells: The Practical Handbook contains the first centralised collection of methods used in human embryonic stem cell...

• Provides an overview of the hierarchy of study designs, and justifies the position of randomised trials at the top of this hierarchy.
• Discusses the strengths and defects of randomisation, and provides real evidence to justify concern...

Illustrated with many authentic examples, the book introduces basic statistical concepts and methods to construct survival curves, later developing them to encompass more specialised and complex models.

During the years since the first edition there have been several new topics that have come to the fore and many new applications. Parallel developments in computer software...

Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents...