Kategoria BISAC: Medical >> Biostatistics

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as...

This textbook takes a unique approach to explaining and demonstrating how to use and interpret statistics for the physiological, medical, and life sciences. The first third of the book presents an integrated overview and introduction to experimental design and statistical inference. The rest of the book provides an extensively cross-referenced set of 100 brief critiques of sample case studies embodying all the most common statistical errors or design problems found in the biological literature. These specific cases are effective for teaching the principles of biostatistics. The examples are...

Public health strives to improve the health of human populations, and prevent disease, disability, and death. Statistics--the science of finding underlying patterns by analyzing variability and errors in collected data--is essential to the understanding of disease patterns in human populations. Other quantitative methods, such as economics, decision theory, and mathematics, now constitute integral parts of the scientific basis for priority-setting and evaluation in public health.
This book provides a broad conceptual treatment of the statistical issues underlying core public health...

Statistical analysis typically involves applying theoretically generated techniques to the description and interpretation of collected data. In this text, theory, application and interpretation are combined to present the entire biostatistical process for a series of elementary and intermediate analytic methods. The theoretical basis for each method is discussed with a minimum of mathematics and is applied to a research data example using a computer system called S-PLUS. This system produces concrete numerical results and increases one's understanding of the fundamental concepts and...

Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te- nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a...

Lowers the Learning Curve for Physicians and Researchers

The successful Statistical Reasoning in Medicine: The Intuitive P-value Primer, with its novel emphasis on patient and community protection, illustrated the correct use of statistics in health care research for healthcare workers. Through clear explanations and examples, this book provided the non-mathematician with a foundation for understanding the underlying statistical reasoning process in clinical research, the core principles of research design, and the correct use of statistical inference and p-values.

The...

Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community.

This book provides an introduction to some of these new methods. The main biological topics treated include sequence...

Quantal response (sometimes called dose-reponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.

Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying...

A mixed model allows the incorporation of both fixed and random variables within a statistical analysis. This enables efficient inferences and more information to be gained from the data. The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This new edition of a groundbreaking text discusses the latest developments, from updated SAS techniques to the increasingly wide range of applications. Presents an...

An up-to-date and comprehensive treatment of biosurveillance techniques

With the worldwide awareness of bioterrorism and drug-resistant infectious diseases, the need for surveillance systems to accurately detect emerging epidemicsis essential for maintaining global safety. Responding to these issues, Disease Surveillance brings together fifteen eminent researchers in the fields of medicine, epidemiology, biostatistics, and medical informatics to define the necessary elements of an effective disease surveillance program, including research, development, implementation, and operations. The...

Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities.

Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects...

Genetic epidemiology is a rapidly developing field, and has continued to grow enormously in international importance over the last ten years. This book provides a unified text that draws together material genetics, epidemiology, public health and statistics. Developed from the authors extensive experience of teaching undergraduate and graduate level courses in genetic epidemiology and statistical genetics, it contains numerous examples drawn from the literature and the authors' personal experience, and features exercises with worked answers.

Features include: A truly introductory level...

Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are...

The need to understand, interpret and analyse competing risk data is key to many areas of science, particularly medical research. There is a real need for a book that presents an overview of methodology used in the interpretation and analysis of competing risks, with a focus on practical applications to medical problems, and incorporating modern techniques. This book fills that need by presenting the most up-to-date methodology, in a way that can be readily understood, and applied, by the practitioner.

A respected introduction to biostatistics, thoroughly updated and revised

The first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today's aspiring and practicing medical scientist.

This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and...

A unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications

The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to...

First published in 1986, this unique reference to clinical experimentation remains just as relevant today. Focusing on the principles of design and analysis of studies on human subjects, this book utilizes and integrates both modern and classical designs. Coverage is limited to experimental comparisons of treatments, or in other words, clinical studies in which treatments are assigned to subjects at random.

While mapped data provide a common ground for discussions between the public, the media, regulatory agencies, and public health researchers, the analysis of spatially referenced data has experienced a phenomenal growth over the last two decades, thanks in part to the development of geographical information systems (GISs). This is the first thorough overview to integrate spatial statistics with data management and the display capabilities of GIS. It describes methods for assessing the likelihood of observed patterns and quantifying the link between exposures and outcomes in spatially...

The new edition adds a chapter on multiple linear regression in biomedical research, with sections including the multiple linear regressions model and least squares; the ANOVA table, parameter estimates, and confidence intervals; partial f-tests; polynomial regression; and analysis of covariance.
* Organized by problem rather than method, so it guides readers to the correct technique for solving the problem at hand.