Kategoria BISAC: Medical >> Biostatistics

Since 1945, "The Annual Deming Conference on Applied Statistics" has been an important event in the statistics profession. In Clinical Trial Biostatistics and Biopharmaceutical Applications, prominent speakers from past Deming conferences present novel biostatistical methodologies in clinical trials as well as up-to-date biostatistical applications from the pharmaceutical industry.

Divided into five sections, the book begins with emerging issues in clinical trial design and analysis, including the roles of modeling and simulation, the pros and cons of...

Missing data have long plagued those conducting applied research in the social, behavioral, and health sciences. Good missing data analysis solutions are available, but practical information about implementation of these solutions has been lacking. The objective of Missing Data: Analysis and Design is to enable investigators who are non-statisticians to implement modern missing data procedures properly in their research, and reap the benefits in terms of improved accuracy and statistical power.

Missing Data: Analysis and Design contains essential information for...

This book offers a thorough and updated guide to the theory and methods of progressive censoring, an area that has experienced tremendous growth over the last decade. Progressive censoring, originally proposed in the1950s, is an efficient method of handling samples arising from industrial experiments involving lifetimes of machines or units that have to be terminated early due to a variety of circumstances. In recent years, the theory has developed quite nicely in some special cases having practical applications to reliability and quality.

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Get Up to Speed on Many Types of Adaptive Designs

Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials.

New to the Second Edition

• Twelve new chapters covering blinded and semi-blinded sample size reestimation...

Praise for the" First Edition"

"Students from health, medical, pharmacy, and nursing will find..."Introductory Biostatistics" extremely useful. Difficult biostatistical concepts are made easier by simple and careful explanations..."

"- Journal of Statistical Computation and Simulation"

Maintaining the same accessible and hands-on presentation, "Introductory Biostatistics, Second Edition" continues to provide an organized introduction to basic statistical concepts commonly applied in research across the health sciences. With plenty of real-world examples, the new edition provides a...

A -how to- guide for applying statistical methods to biomarker data analysis

Presenting a solid foundation for the statistical methods that are used to analyze biomarker data, Analysis of Biomarker Data: A Practical Guide features preferred techniques for biomarker validation. The authors provide descriptions of select elementary statistical methods that are traditionally used to analyze biomarker data with a focus on the proper application of each method, including necessary assumptions, software recommendations, and proper interpretation of computer output. In...

Mathematical epidemiology of infectious diseases usually involves describing the flow of individuals between mutually exclusive infection states. One of the key parameters describing the transition from the susceptible to the infected class is the hazard of infection, often referred to as the force of infection. The force of infection reflects the degree of contact with potential for transmission between infected and susceptible individuals. The mathematical relation between the force of infection and effective contact patterns is generally assumed to be subjected to the mass action...

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials.

The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly...

This volume presents the latest advances and trends in stochastic models and related statistical procedures. Selected peer-reviewed contributions focus on statistical inference, quality control, change-point analysis and detection, empirical processes, time series analysis, survival analysis and reliability, statistics for stochastic processes, big data in technology and the sciences, statistical genetics, experiment design, and stochastic models in engineering.

Stochastic models and related statistical procedures play an important part in furthering our understanding of the...

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the...

As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA conference plays a role in this evolving field by providing a forum in which investors can analyze the same data sets using different methods. Methods of Microarray Data Analysis IV is the fourth book in this series, and focuses on the important issue of associating array data with a survival endpoint. Previous books in this series focused on classification (Volume I), pattern recognition (Volume II), and quality control issues (Volume...

The "Handbook of Scan Statistics" in two volumes is intended for researchers in probability and statistics and scientists in several areas including biology, engineering, health, medical, and social sciences. It will be of great value to graduate students in statistics and in all areas where scan statistics are used.

The specialized field called 'scan statistics', fathered by Joseph Naus around 1999, burgeoned rapidly to prominence in the broader fields of applied probability and statistics. In additional to challenging theoretical problems, scan statistics has exciting applications...

This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of rare variants, such as the impact of fine-scale population structure,...