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Foundations of Comparative Genomics
ISBN: 9780120887941 / Angielski / Twarda / 280 str. This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several stateoftheart issues, such as...
This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Founda...


cena:
375,32 zł 
Biostatistics: Experimental Design and Statistical Inference
ISBN: 9780195078107 / Angielski / Twarda / 368 str. This textbook takes a unique approach to explaining and demonstrating how to use and interpret statistics for the physiological, medical, and life sciences. The first third of the book presents an integrated overview and introduction to experimental design and statistical inference. The rest of the book provides an extensively crossreferenced set of 100 brief critiques of sample case studies embodying all the most common statistical errors or design problems found in the biological literature. These specific cases are effective for teaching the principles of biostatistics. The examples are...
This textbook takes a unique approach to explaining and demonstrating how to use and interpret statistics for the physiological, medical, and life sci...


cena:
1141,14 zł 
Statistics in Public Health
ISBN: 9780195114980 / Angielski / Miękka / 256 str. Public health strives to improve the health of human populations, and prevent disease, disability, and death. Statisticsthe science of finding underlying patterns by analyzing variability and errors in collected datais essential to the understanding of disease patterns in human populations. Other quantitative methods, such as economics, decision theory, and mathematics, now constitute integral parts of the scientific basis for prioritysetting and evaluation in public health.
This book provides a broad conceptual treatment of the statistical issues underlying core public health... Public health strives to improve the health of human populations, and prevent disease, disability, and death. Statisticsthe science of finding under...


cena:
361,39 zł 
Modern Applied Biostatistical Methods: Using SPlus
ISBN: 9780195120257 / Angielski / Twarda / 480 str. Statistical analysis typically involves applying theoretically generated techniques to the description and interpretation of collected data. In this text, theory, application and interpretation are combined to present the entire biostatistical process for a series of elementary and intermediate analytic methods. The theoretical basis for each method is discussed with a minimum of mathematics and is applied to a research data example using a computer system called SPLUS. This system produces concrete numerical results and increases one's understanding of the fundamental concepts and...
Statistical analysis typically involves applying theoretically generated techniques to the description and interpretation of collected data. In this t...


cena:
454,53 zł 
Telemedicine: Medicine and Communication
ISBN: 9780306465529 / Angielski / Twarda / 213 str. Within the various aspects of lifescience technologies medicine and information technology will change next millennium's qualityoflife fundamentally. Thanks to the rapid growth of telecommunication industry and the success and popularity of the internet the face of medicine will essentially change, because information technology is expected to play a major role in future health care systems. The conference MEDICOM 2000 is a discussion forum on fast and cost efficient patientdata exchange systems between doctors' offices, medical laboratories, telearchive services, health care insurances,...
Within the various aspects of lifescience technologies medicine and information technology will change next millennium's qualityoflife fundamentall...


cena:
650,99 zł 
Multiple Analyses in Clinical Trials: Fundamentals for Investigators
ISBN: 9780387007274 / Angielski / Twarda / 436 str. One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessment of a subgroup analysis, and the evaluation of a doseresponse relationship in complex mixtures. Multiple Analyses in Clinical Trials: Fundamentals for Clinical Investigators is an essentially nonmathematical discussion of the problems posed by the execution of multiple analyses in clinical...
One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results ...


cena:
466,16 zł 
Dynamic Regression Models for Survival Data
ISBN: 9780387202747 / Angielski / Twarda / 470 str. In survival analysis there has long been a need for models that goes beyond the Cox model as the proportional hazards assumption often fails in practice. This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the specific aim of describing timevarying effects of explanatory variables. One model that receives special attention is Aalen's additive hazards model that is particularly well suited for dealing with timevarying effects. The book covers the use of residuals and resampling... In survival analysis there has long been a need for models that goes beyond the Cox model as the proportional hazards assumption often fails in pra... 

cena:
650,12 zł 
Data Monitoring in Clinical Trials: A Case Studies Approach
ISBN: 9780387203300 / Angielski / Miękka / 374 str. Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts,... Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obt... 

cena:
360,38 zł 
Statistical Genetics of Quantitative Traits: Linkage, Maps and QTL
ISBN: 9780387203348 / Angielski / Twarda / 365 str. Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a...
Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of th...


cena:
926,06 zł 
Bioinformatics and Computational Biology Solutions Using R and Bioconductor
ISBN: 9780387251462 / Angielski / Twarda / 473 str. Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from highthroughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of highthroughput data from microarray, proteomic, and flow cytometry platforms: Curation and delivery of biological metadata for use in statistical... Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from highthroug... 

cena:
742,10 zł 
Proportional Hazards Regression
ISBN: 9780387251486 / Angielski / Twarda / 542 str. Proportional hazards models and their extensions (models with ti dependent covariates, models with time dependent regression co cients, models with random coe?cients and any mixture of these) can be used to characterize just about any applied problem to which the techniques of survival analysis are appropriate. This simple obser tion enables us to ?nd an elegant statistical expression for all plausible practical situations arising in the analysis of survival data. We have a single unifying framework. In consequence, a solid understanding of the framework itself o?ers the statistician the...
Proportional hazards models and their extensions (models with ti dependent covariates, models with time dependent regression co cients, models with ...


cena:
512,15 zł 
Probability, Statistics and Modelling in Public Health
ISBN: 9780387260228 / Angielski / Twarda / 480 str. Probability, Statistics and Modelling in Public Health consists of refereed contributions by expert biostatisticians that discuss various probabilistic and statistical models used in public health. Many of them are based on the work of Marvin Zelen of the Harvard School of Public Health. Topics discussed include models based on Markov and semiMarkov processes, multistate models, models and methods in lifetime data analysis, accelerated failure models, design and analysis of clinical trials, Bayesian methods, pharmaceutical and environmental statistics, degradation models,...
Probability, Statistics and Modelling in Public Health consists of refereed contributions by expert biostatisticians that discuss var...


cena:
788,09 zł 
Statistical Monitoring of Clinical Trials: Fundamentals for Investigators
ISBN: 9780387277813 / Angielski / Miękka / 254 str. Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures now required by the many clinical research efforts. The author provides motivated clinical investigators the background, correct use, and interpretation of these monitoring procedures at an elementary statistical level. He... Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in ... 

cena:
420,17 zł 
Dose Finding in Drug Development
ISBN: 9780387290744 / Angielski / Twarda / 248 str. This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdoseresponsestudies. The importance of this subject can be found from the International Conference on Harmonization (ICH) E4 Guidance document. Establishing the doseresponse relationship is one of the most important act ities in developing a new drug. A clinical development program for a new drug can be broadly divided into four phases  namely Phases I, II, III, and IV. Phase I clinical trials are designed to study the clinical pharmacology. Information ...
This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdoseresponsest...


cena:
788,09 zł 
Statistical Monitoring of Clinical Trials: A Unified Approach
ISBN: 9780387300597 / Angielski / Twarda / 258 str. The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the Bvalue") irrespective of the test statistic. The socalled Bvalue approach to monitoring allows us to use, for different... The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the... 

cena:
558,14 zł 
The Statistical Analysis of IntervalCensored Failure Time Data
ISBN: 9780387329055 / Angielski / Twarda / 304 str. This book collects and unifies statistical models and methods that have been proposed for analyzing intervalcensored failure time data. It provides the first comprehensive coverage of the topic of intervalcensored data and complements the books on rightcensored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an uptodate reference for people who are conducting research on the analysis of intervalcensored failure time data as well as for those who need to analyze... This book collects and unifies statistical models and methods that have been proposed for analyzing intervalcensored failure time data. It provide... 

cena:
765,09 zł 
Statistical Reasoning in Medicine: The Intuitive PValue Primer
ISBN: 9780387329130 / Angielski / Miękka / 301 str. Lowers the Learning Curve for Physicians and Researchers The successful Statistical Reasoning in Medicine: The Intuitive Pvalue Primer, with its novel emphasis on patient and community protection, illustrated the correct use of statistics in health care research for healthcare workers. Through clear explanations and examples, this book provided the nonmathematician with a foundation for understanding the underlying statistical reasoning process in clinical research, the core principles of research design, and the correct use of statistical inference and pvalues. The... Lowers the Learning Curve for Physicians and Researchers The successful Statistical Reasoning in Medicine: The Intuitive Pvalue Primer, wi... 

cena:
420,17 zł 
Statistical Methods in Bioinformatics: An Introduction
ISBN: 9780387400822 / Angielski / Twarda / 598 str. Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence... Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated t... 

cena:
512,15 zł 
A Pocket Guide to Epidemiology
ISBN: 9780387459646 / Angielski / Miękka / 281 str. A Pocket Guide to Epidemiology is a standalone introductory text on the basic principles and concepts of epidemiology. The primary audience for this text is the public health student or professional, clinician, health journalist, and anyone else at any age or life experience that is interested in learning what epidemiology is all about in a convenient, easy to understand format with timely, realworld health examples.
A Pocket Guide to Epidemiology is a standalone introductory text on the basic principles and concepts of epidemiology. The primary audience fo...


cena:
259,20 zł 
Analyzing Ecological Data
ISBN: 9780387459677 / Angielski / Twarda / 672 str. 'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the question that the authors of this book hear the most often. The answer is always the same and along the lines of 'What are your underlying questions?', 'What do you want to show?'. The answers to these questions provide the starting point for a detailed discussion on the ecological background and purpose of the study. This then gives the basis for deciding on the most appropriate analytical approach. Therefore, a better start ing point for an...
'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the que...


cena:
1152,54 zł 