Foundations of Comparative Genomics
ISBN: 9780120887941 / Angielski / Twarda / 280 str. Termin realizacji zamówienia: ok. 58 dni roboczych. This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several stateoftheart issues, such as...
This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Founda...


cena:
646,77 zł 
Biostatistics: Experimental Design and Statistical Inference
ISBN: 9780195078107 / Angielski / Twarda / 368 str. Termin realizacji zamówienia: ok. 58 dni roboczych. This textbook takes a unique approach to explaining and demonstrating how to use and interpret statistics for the physiological, medical, and life sciences. The first third of the book presents an integrated overview and introduction to experimental design and statistical inference. The rest of the book provides an extensively crossreferenced set of 100 brief critiques of sample case studies embodying all the most common statistical errors or design problems found in the biological literature. These specific cases are effective for teaching the principles of biostatistics. The examples are...
This textbook takes a unique approach to explaining and demonstrating how to use and interpret statistics for the physiological, medical, and life sci...


cena:
1560,76 zł 
Statistics in Public Health
ISBN: 9780195114980 / Angielski / Miękka / 256 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Public health strives to improve the health of human populations, and prevent disease, disability, and death. Statisticsthe science of finding underlying patterns by analyzing variability and errors in collected datais essential to the understanding of disease patterns in human populations. Other quantitative methods, such as economics, decision theory, and mathematics, now constitute integral parts of the scientific basis for prioritysetting and evaluation in public health.
This book provides a broad conceptual treatment of the statistical issues underlying core public health... Public health strives to improve the health of human populations, and prevent disease, disability, and death. Statisticsthe science of finding under...


cena:
448,95 zł 
Modern Applied Biostatistical Methods: Using SPlus
ISBN: 9780195120257 / Angielski / Twarda / 480 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Statistical analysis typically involves applying theoretically generated techniques to the description and interpretation of collected data. In this text, theory, application and interpretation are combined to present the entire biostatistical process for a series of elementary and intermediate analytic methods. The theoretical basis for each method is discussed with a minimum of mathematics and is applied to a research data example using a computer system called SPLUS. This system produces concrete numerical results and increases one's understanding of the fundamental concepts and...
Statistical analysis typically involves applying theoretically generated techniques to the description and interpretation of collected data. In this t...


cena:
454,85 zł 
Dynamic Regression Models for Survival Data
ISBN: 9780387202747 / Angielski / Twarda / 488 str. Termin realizacji zamówienia: ok. 58 dni roboczych. In survival analysis there has long been a need for models that goes beyond the Cox model as the proportional hazards assumption often fails in practice. This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the specific aim of describing timevarying effects of explanatory variables. One model that receives special attention is Aalen's additive hazards model that is particularly well suited for dealing with timevarying effects. The book covers the use of residuals and resampling... In survival analysis there has long been a need for models that goes beyond the Cox model as the proportional hazards assumption often fails in pra... 

cena:
607,75 zł 
Data Monitoring in Clinical Trials: A Case Studies Approach
ISBN: 9780387203300 / Angielski / Miękka / 404 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts,... Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obt... 

cena:
344,38 zł 
Statistical Genetics of Quantitative Traits: Linkage, Maps and QTL
ISBN: 9780387203348 / Angielski / Twarda / 368 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a...
Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of th...


cena:
810,35 zł 
Bioinformatics and Computational Biology Solutions Using R and Bioconductor
ISBN: 9780387251462 / Angielski / Twarda / 474 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from highthroughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of highthroughput data from microarray, proteomic, and flow cytometry platforms: Curation and delivery of biological metadata for use in statistical... Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from highthroug... 

cena:
810,35 zł 
Proportional Hazards Regression
ISBN: 9780387251486 / Angielski / Twarda / 542 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Proportional hazards models and their extensions (models with ti dependent covariates, models with time dependent regression co cients, models with random coe?cients and any mixture of these) can be used to characterize just about any applied problem to which the techniques of survival analysis are appropriate. This simple obser tion enables us to ?nd an elegant statistical expression for all plausible practical situations arising in the analysis of survival data. We have a single unifying framework. In consequence, a solid understanding of the framework itself o?ers the statistician the...
Proportional hazards models and their extensions (models with ti dependent covariates, models with time dependent regression co cients, models with ...


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405,15 zł 
Dose Finding in Drug Development
ISBN: 9780387290744 / Angielski / Twarda / 248 str. Termin realizacji zamówienia: ok. 58 dni roboczych. This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdoseresponsestudies. The importance of this subject can be found from the International Conference on Harmonization (ICH) E4 Guidance document. Establishing the doseresponse relationship is one of the most important act ities in developing a new drug. A clinical development program for a new drug can be broadly divided into four phases  namely Phases I, II, III, and IV. Phase I clinical trials are designed to study the clinical pharmacology. Information ...
This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdoseresponsest...


cena:
688,79 zł 
Statistical Monitoring of Clinical Trials: A Unified Approach
ISBN: 9780387300597 / Angielski / Twarda / 268 str. Termin realizacji zamówienia: ok. 58 dni roboczych. The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the Bvalue") irrespective of the test statistic. The socalled Bvalue approach to monitoring allows us to use, for different... The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the... 

cena:
526,71 zł 
Statistical Reasoning in Medicine: The Intuitive PValue Primer
ISBN: 9780387329130 / Angielski / Miękka / 302 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Lowers the Learning Curve for Physicians and Researchers The successful Statistical Reasoning in Medicine: The Intuitive Pvalue Primer, with its novel emphasis on patient and community protection, illustrated the correct use of statistics in health care research for healthcare workers. Through clear explanations and examples, this book provided the nonmathematician with a foundation for understanding the underlying statistical reasoning process in clinical research, the core principles of research design, and the correct use of statistical inference and pvalues. The... Lowers the Learning Curve for Physicians and Researchers The successful Statistical Reasoning in Medicine: The Intuitive Pvalue Primer, wi... 

cena:
202,56 zł 
Statistical Methods in Bioinformatics: An Introduction
ISBN: 9780387400822 / Angielski / Twarda / 598 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence... Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated t... 

cena:
486,19 zł 
A Pocket Guide to Epidemiology
ISBN: 9780387459646 / Angielski / Miękka / 284 str. Termin realizacji zamówienia: ok. 58 dni roboczych. A Pocket Guide to Epidemiology is a standalone introductory text on the basic principles and concepts of epidemiology. The primary audience for this text is the public health student or professional, clinician, health journalist, and anyone else at any age or life experience that is interested in learning what epidemiology is all about in a convenient, easy to understand format with timely, realworld health examples.
A Pocket Guide to Epidemiology is a standalone introductory text on the basic principles and concepts of epidemiology. The primary audience fo...


cena:
324,11 zł 
Analyzing Ecological Data
ISBN: 9780387459677 / Angielski / Twarda / 700 str. Termin realizacji zamówienia: ok. 58 dni roboczych. 'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the question that the authors of this book hear the most often. The answer is always the same and along the lines of 'What are your underlying questions?', 'What do you want to show?'. The answers to these questions provide the starting point for a detailed discussion on the ecological background and purpose of the study. This then gives the basis for deciding on the most appropriate analytical approach. Therefore, a better start ing point for an...
'Which test should I apply?' During the many years of working with ecologists, biologists and other environmental scientists, this is probably the que...


cena:
1399,02 zł 
The Statistics of Gene Mapping
ISBN: 9780387496849 / Angielski / Twarda / 334 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of... Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic... 

cena:
607,75 zł 
The Frailty Model
ISBN: 9780387728346 / Angielski / Twarda / 336 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. Frailty models provide a powerful tool to analyse clustered survival data. In contrast to the large number of research publications on frailty models, relatively few statistical software packages contain frailty models. It is demanding for statistical practitioners and graduate students to grasp a good knowledge on frailty models from the existing literature. This book provides an indepth discussion and explanation of... Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public healt... 

cena:
405,15 zł 
Evaluating Clinical Research: All That Glitters Is Not Gold
ISBN: 9780387728988 / Angielski / Miękka / 165 str. Termin realizacji zamówienia: ok. 58 dni roboczych. This book aims to make the readers better informed and more critical consumers of clinical research. It will help the reader recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patientimportant and methodologically sound studies from those having limitations in design, conduct and interpretation. The text is basic and has no statistical formulas. Key takehome messages are listed at the end of each chapter. Cartoons make the text easier to read and generate a few laughs, and they underscore specific points, sometimes... This book aims to make the readers better informed and more critical consumers of clinical research. It will help the reader recognize the strength... 

cena:
303,86 zł 
Analysis of Quantal Response Data
ISBN: 9780412317507 / Angielski / Twarda / 532 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Quantal response (sometimes called dosereponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.
Quantal response (sometimes called dosereponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is...


cena:
405,15 zł 
Statistical Methods in Spatial Epidemiology
ISBN: 9780470014844 / Angielski / Twarda / 424 str. Termin realizacji zamówienia: ok. 58 dni roboczych. Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bioterrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying...
Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern thre...


cena:
579,64 zł 