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Stability of Protein Pharmaceuticals: Part B: In Vivo Pathways of Degradation and Strategies for Protein Stabilization
ISBN: 9780306441530 / Angielski / Twarda / 328 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.
Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, ...
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805,10 |
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Stability and Characterization of Protein and Peptide Drugs: Case Histories
ISBN: 9780306443657 / Angielski / Twarda / 353 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar keted or are under clinical testing. In previous volumes of this series, funda mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is...
This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar ...
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805,10 |
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Models for Assessing Drug Absorption and Metabolism
ISBN: 9780306452437 / Angielski / Twarda / 444 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.
Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting bioph...
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805,10 |
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Formulation, Characterization, and Stability of Protein Drugs: Case Histories
ISBN: 9780306453328 / Angielski / Twarda / 432 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential hot spots' in proteins, this accessible compilation allows for inspection of the protein's...
Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are desc...
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805,10 |
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Erythrocytes as Drug Carriers in Medicine
ISBN: 9780306455995 / Angielski / Twarda / 150 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Erythrocytes (ISURE) on July 25-28, 1996. Although earlier meetings focused on the technology toward develop ment of methods and standardization for efficient, consistent encapsulation, most of the present studies now are directed toward the application use of these carrier blood cells. Basic studies now have been directed toward exploration of commercial applications. In deed, clinical trials were initiated to evaluate the dose-response curves...
The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Eryt...
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cena:
805,10 |
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Integration of Pharmaceutical Discovery and Development: Case Histories
ISBN: 9780306457432 / Angielski / Twarda / 610 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g., high affinity and specificity for the target receptor), pharmaceutical (e....
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented...
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805,10 |
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Immunotoxicology and Risk Assessment
ISBN: 9780306459719 / Angielski / Twarda / 382 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US...
This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on haza...
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805,10 |
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Membrane Transporters as Drug Targets
ISBN: 9780306460944 / Angielski / Twarda / 530 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure,...
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805,10 |
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Phytochemicals in Human Health Protection, Nutrition, and Plant Defense
ISBN: 9780306462030 / Angielski / Twarda / 432 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since 1994, the Phytochemical Society of North America has devoted its annual symposia to topics with biological perspectives. Our last four volumes have dealt with medicinal plants (1994), plant/insect interactions (1995), food phytochemicals (1996), and plant/microbe interactions (1997), respectively. The Symposium held in Pullman, Washington, July 26-31, 1998 brought many aspects of these previous symposia once again to the forefront. This time, however, there was greater emphasis on the potential applications of phytochemistry to the diverse topics of human health and nutrition and plant...
Since 1994, the Phytochemical Society of North America has devoted its annual symposia to topics with biological perspectives. Our last four volumes h...
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805,10 |
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Cryopreservation and Low Temperature Biology in Blood Transfusion: Proceedings of the Fourteenth International Symposium on Blood Transfusion, Groning
ISBN: 9780792309086 / Angielski / Twarda / 291 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiology pioneer Dr. Herman W. Krijnen of the Dutch Red Cross Central Laboratory. Dr. Krijnen was known and respected in the national and interna tional blood transfusion community as an extremely competent scientist and a beloved and admired colleague. Dr. Krijnen was intentionally honoured with the invitation to open this symposium on cryopreservation and low temperature biology in blood transfusion and be the guest of honour at this event....
The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiolo...
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805,10 |
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Copper and Zinc in Inflammatory and Degenerative Diseases
ISBN: 9780792348276 / Angielski / Twarda / 197 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states.
This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to... Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varie...
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805,10 |
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Side Effects of Anti-Inflammatory Drugs IV: The Proceedings of the Ivth International Meeting on Side Effects of Anti-Inflammatory Drugs, Held in Shef
ISBN: 9780792387138 / Angielski / Twarda / 356 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Recent concern about the adverse effects and relative risks of anti- inflammatory therapies has been such that another meeting was organized in the highly successful series of meetings on this topic. Adverse effects of anti-rheumatic and anti-inflammatory drugs are of major concern to all involved in the prescription, care and management of rheumatic and other patients receiving these important drugs. The IVth International Meeting on Side-Effects of Anti-Inflammatory Drugs, held in Sheffield, UK, 7-9 August 1995, afforded a unique opportunity to hear the latest information and views on...
Recent concern about the adverse effects and relative risks of anti- inflammatory therapies has been such that another meeting was organized in the hi...
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805,10 |
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Marihuana and Medicine
ISBN: 9780896035935 / Angielski / Twarda / 826 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading physicians and scientists from around the world critically examine the pharmacological and molecular basis of the therapeutic properties of marihuana and its active ingredient, THC. They detail the broad array of marihuana's effects on brain function, the immune system, male and female reproductive functions, and cardiac and pulmonary functions, as well as evaluate its clinical applications in psychiatry, glaucoma, pain management, cancer chemotherapy, and AIDS treatment. Their studies indicate that marihuana persistently impairs the brain and reproductive function, and that marihuana...
Leading physicians and scientists from around the world critically examine the pharmacological and molecular basis of the therapeutic properties of ma...
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805,10 |
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Handbook of Copper Pharmacology and Toxicology
ISBN: 9780896039438 / Angielski / Twarda / 608 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in...
Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge conce...
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805,10 |
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Diuretics: Basic, Pharmacological, and Clinical Aspects: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26-30, 1986
ISBN: 9780898388855 / Angielski / Twarda / 576 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana," the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill." But calomel had a...
The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana," the oldest medieval medical school in West...
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805,10 |
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Optimization of Aerosol Drug Delivery
ISBN: 9781402016516 / Angielski / Twarda / 315 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy.
The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the... Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is ...
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805,10 |
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Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 9781402078040 / Angielski / Twarda / 318 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work.
This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption,... Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working...
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805,10 |
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Chemoradiation in Cancer Therapy
ISBN: 9781588290281 / Angielski / Twarda / 420 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Internationally recognized experts in radiobiology describe herein the effects of tumour radiosensitivity with chemotherapeutic agents as well as combined modality therapy. The book details the current applications of combined modality therapy in a variety of tumour types. It demonstrates the integration of new specific molecular targeted agents into the mutimodality therapy, thus providing a new class of molecular targeted agents for radiation oncologists.
Internationally recognized experts in radiobiology describe herein the effects of tumour radiosensitivity with chemotherapeutic agents as well as comb...
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805,10 |
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Medicinal Plants of the World: Volume 1: Chemical Constituents, Traditional and Modern Medicinal Uses
ISBN: 9781588292810 / Angielski / Twarda / 508 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Ivan Ross takes advantage of the significant growth in the amount of new data available to update and expand his much acclaimed Medicinal Plants of the World: Chemical Constituents, Traditional and Modern Medicinal Uses. This second edition exhaustively compiles new clinical research and references twenty-six of the most widely used medicinal plants in the world, including Allium sativum, Mangifera indica, Punica granatum;, Momoridica charantia, Mucuna pruriens; Arbus precatorius; Moringa pterysgosperma, Phyllanthus niruri, and Jatrpha curcas.
Ivan Ross takes advantage of the significant growth in the amount of new data available to update and expand his much acclaimed Medicinal Plants of th...
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805,10 |
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Drugs of Abuse: Body Fluid Testing
ISBN: 9781588294357 / Angielski / Twarda / 306 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best...
A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for d...
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cena:
805,10 |