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Physiology and Pharmacology of Biological Rhythms
ISBN: 9783540615255 / Angielski / Twarda / 668 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is...
Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansi...
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cena:
1932,22 zł |
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Prodrugs: Challenges and Rewards
ISBN: 9780387497822 / Angielski / Twarda / 1464 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes... Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behin... |
cena:
1932,22 zł |
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Transient Receptor Potential (TRP) Channels
ISBN: 9783540348894 / Angielski / Twarda / 623 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds,... In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmaco... |
cena:
1932,22 zł |
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Adenosine Receptors in Health and Disease
ISBN: 9783540896142 / Angielski / Twarda / 652 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of... Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug dis... |
cena:
1932,22 zł |
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Atherosclerosis: Diet and Drugs
ISBN: 9783540225690 / Angielski / Twarda / 816 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity...
Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology,...
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cena:
1932,22 zł |
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Drug Discovery and Evaluation: Methods in Clinical Pharmacology
ISBN: 9783540898900 / Angielski / Twarda / 564 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well... Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be de... |
cena:
1932,22 zł |
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Pharmacology of Ionic Channel Function: Activators and Inhibitors
ISBN: 9783540661276 / Angielski / Twarda / 662 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their function...
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cena:
1932,22 zł |
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Antisense Research and Application
ISBN: 9783540638339 / Angielski / Twarda / 630 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to ...
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cena:
1932,22 zł |
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Pharmacology and Therapeutics of Asthma and Copd
ISBN: 9783540004646 / Angielski / Twarda / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology. The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also dis... |
cena:
1932,22 zł |
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Pharmacology and Therapeutics of Asthma and Copd
ISBN: 9783642055904 / Angielski / Miękka / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology. The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also dis... |
cena:
1932,22 zł |
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Ionotropic Glutamate Receptors in the CNS
ISBN: 9783642085390 / Angielski / Miękka / 535 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It is now widely accepted that glutamate is the major excitatory neurotrans mitter in the mammalian central nervous system. The main criteria for accept ing a molecule as a chemical transmitter appear to be fulfilled at several synapses: Glutamate mimics the action of the natural transmitter in the post synaptic neuron (CURTIS et al. 1959), glutamate is present in presynaptic ele ments (OTTERSEN and STORM-MATHISEN 1984), and glutamate is released from central neurons in an activity-dependent manner (BRADFORD 1970). The postsynaptic receptors that mediate the effects of glutamate are markedly...
It is now widely accepted that glutamate is the major excitatory neurotrans mitter in the mammalian central nervous system. The main criteria for acce...
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cena:
1932,22 zł |
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Physiology and Pharmacology of Biological Rhythms
ISBN: 9783642082658 / Angielski / Miękka / 668 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is...
Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansi...
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cena:
1932,22 zł |
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Transient Receptor Potential (TRP) Channels
ISBN: 9783642071140 / Angielski / Miękka / 623 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds,... In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmaco... |
cena:
1932,22 zł |
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Inhibitors of Protein Kinases and Protein Phosphates
ISBN: 9783642422065 / Angielski / Miękka / 458 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles. The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide ... |
cena:
1932,22 zł |
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Biomarkers in Nutrition
ISBN: 9783031073885 / Angielski / Twarda / 1182 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into the area of circulating body fluid biomarkers, from cardiovascular related markers to liver functional tests. Various biomarkers related to the intake of micronutrient and macronutrients are presented, and the effects of different diets, pesticide exposure and dietary supplements are discussed, so are changes of genetic, cellular and histological variables.This systematic handbook is a must have for biomedical researchers as well as clinicians...
This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into t...
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cena:
1932,22 zł |
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Sensory Nerves
ISBN: 9783540790891 / Angielski / Twarda / 640 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Theintentionofthisbookistoprovideacomprehensiveandcontemporaryreview ofthebiologyofsensorynerves. InkeepingwiththethemeoftheHandbookof Experimental Pharmacology series, emphasis will be placed on the actions of drugs, transmittersandautacoidsthatinitiateorinhibitsensorynerveactivation (through actionsonionchannelsandreceptorsattheirperipheralterminals)or modulate the release or actions of the transmitters released from the central terminalsofsensorynerves. Onthebasisofextensivesupportiveevidenceinthe literature, it is our view that many diseases are characterized by alterations in...
Theintentionofthisbookistoprovideacomprehensiveandcontemporaryreview ofthebiologyofsensorynerves. InkeepingwiththethemeoftheHandbookof Experimental Ph...
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cena:
1932,22 zł |
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Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications
ISBN: 9783642177330 / Angielski / Book / 3934 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This 6 volume set offers a systematic, standardized description of 23,033 chemical components isolated from 6,926 medicinal plants, collected from 5,535 books and articles published in Chinese and international journals, organized for easy retrieval and use.
This 6 volume set offers a systematic, standardized description of 23,033 chemical components isolated from 6,926 medicinal plants, collected from 5,5...
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cena:
1932,22 zł |
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Antisense Research and Application
ISBN: 9783642637308 / Angielski / Miękka / 630 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to ...
|
cena:
1932,22 zł |
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Atherosclerosis: Diet and Drugs
ISBN: 9783642438974 / Angielski / Miękka / 816 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity...
Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology,...
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cena:
1932,22 zł |
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Biomarkers in Kidney Disease
ISBN: 9789400776982 / Angielski / Twarda / 1215 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In some countries such as the United States, kidney disease kills more people than cancers of the prostate or breast. In the United States for example there are over 15 million individuals with kidney disease. Translated to a worldwide basis, kidney disease of various aetiologies represent a significant burden on healthcare systems, affecting mortality, morbidity and also the family unit. It is therefore imperative that appropriate use is made of conventional, new and emerging biomarker platforms to aid diagnosis, treatment and an understanding of outcome measures. Biomarkers in Kidney...
In some countries such as the United States, kidney disease kills more people than cancers of the prostate or breast. In the United States for example...
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cena:
1932,22 zł |