Kategoria BISAC: Medical >> Clinical Medicine

Laboratory Investigation is a big tool for biological and medical work around the world. The present concept of laboratory investigation is to provide the best analysis. This covers several facets and all phases of the laboratory cycle. This book discusses

Most young people expect to become parents later in
life. However, in industrialized countries 17-26% of
those couples having tried to get a child will be
infertile. They will not have achieved a pregnancy
after more than 1 year of trying. Besides being a
medical condition infertility is a social situation.
For many couples infertility causes serious strain on
their interpersonal relationships. This doctoral
thesis provides information about infertility and
assisted reproduction in Denmark. This country has
the highest percentage of fertility treatment
compared to the size of the population,...

Translated by Henry B. Monges

CONTENTS:

Introduction by Professor Dr. Trumpp, Munich
Author's prefaces
1. A Method of Producing "Sensitive" Crystalizations
2. Experiments with the Blood of the Healthy and the Diseased
3. Further Specific Crystalization Research
4. The effect of Remedies and its Help in Judging Crystializations
5. Technical Details
Bibliography

Recently, studies have pointed to greater knee joint
laxity (KJL) as a potential contributor to the
higher rate of ACL injury among female athletes with
some researchers reporting that hormones influence
joint laxity throughout the menstrual cycle.
However, how changes in KJL during the menstrual
cycle affect knee joint loading, which ultimately
leads to ACL injury, has not been investigated.

Increased KJL was observed during ovulation in most
female subjects; however, subject variations
corresponding to hormonal fluctuations were
detected. When this subject variation was...

Nitric oxide (NO) produced by endothelial nitric
oxide synthase (eNOS) is a key mediator of vascular
homeostasis. eNOS enzymatic activity appears to be
determined by the availability of its cofactor
tetrahydrobiopterin (BH4). BH4 bioavailability is
limited by oxidative degradation in dysfunctional
endothelium, and by alterations in the rate of its
biosynthesis, governed by the rate-limiting enzyme
GTP cyclohydrolase 1 (GTPCH). In this project novel
targeted transgenic mouse lines were generated with
endothelial-specific over-expression of human GTPCH.
These studies have shown that BH4...

Cardiovascular heart disease (CHD) is a chief public
health priority
worldwide. The 12-Lead Electrocardiogram (ECG) is a
standard
procedure in diagnosing CHDs such as Myocardial
Infarction (MI).
Nevertheless, due to sparse spatial sampling, it is
limited in
identifying cardiac abnormalities. Alternatively, in
Body Surface
Cardiac Mapping (BSCM) a higher number of ECGs are
recorded.
Hence, BSCM provides a more comprehensive picture of
electrocardiographic information than is possible
with the 12-lead
ECG. This work has two main objectives. Firstly, to
develop a
classification...

John R. Crowther provides today's premier practical guide to the understanding and application of ELISA. Updating and greatly expanding his widely appreciated earlier publication, ELISA Theory and Practice (1995), this important work introduces chapters on such major new topics as checkerboard titrations, quality control of testing, kit production and control, novel monoclonal antibodies, validation of assays, statistical requirements for data examination, and epidemiological considerations. With its numerous worked examples, detailed instructions, and extensive illustrations, The ELISA...

What will happen during and after a clinical trial? How will a trial affect my quality of life? What are the benefits and risks of a trial? What does giving consent mean and what will it involve? Will I incur costs during and because of the trial? These are the questions that should be raised every time a health care professional talks through with a patient the pros and cons of entering a clinical trial. Clinical Trials Explained has been designed in consultation with doctors and patients who have taken part in trials, providing an essential and detailed guide to the clinical trials process....

Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

• Leading experts from academia and clinical laboratory science
• Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Early detection of colorectal cancer is a strategy
for reducing death of the disease. Detection in this
book refers to both clinical diagnosing and to
presymptomatic detection of colorectal neoplasia.

Five research projects, different in character are
described. A population-based audit of the
diagnostic process includes work-up times, the use
of family history for risk assessment and the
benefit of faecal occult blood test in symptomatic
patients. The next study is an estimation of the
importance of symptom duration in colorectal cancer
on prognosis and it includes a description...

Are coma patients still able of cognition and emotion
and to what extend? Such questions can be
investigated with auditory Event-Related Potentials
(ERPs) and Skin Conductance Response (SCR). Cognitive
functions were tested with several paradigms in 44
coma patients and emotional response in fifteen of
them. In at least 7 % (N=44) of these patients an
explicit semantic processing and thus a minimal
remaining consciousness could not be excluded. This
study is the first to demonstrate semantic processing
in coma. We found a correlation between emotional SCR
and level of consciousness as...

Das Buch gibt dem Kliniker und dem Laboratoriumsmediziner in der taglichen Praxis eine schnelle und fundierte Orientierung uber den umfangreichen Wissensstand der klinischen Liquordiagnostik.

Methoden und Indikationsstellungen zur Gewinnung des Liquor cerebrospinalis sowie die Analyseverfahren, Messparameter und Befundkonstellationen werden ausfuhrlich dargestellt. Das Buch ermoglicht ein tiefes Eindringen in methodische und interpretatorische Aspekte aller klinisch bedeutsamen Liquorparameter. Der aktuellen Entwicklung von Immunologie, Molekularbiologie und Proteinanalytik wird in...

Volume 48 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology.

* Leading experts from academia and clinical laboratory science * Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

This book describes the role of extracellular and
intracellular calcium in hypoxic pulmonary
vasoconstriction (HPV) which can lead to pulmonary
hypertension. In the lungs, HPV can markedly raise
pulmonary arterial pressure. A temporary, moderate
rise in pressure may not be damaging; however,
persistent hypertension (due to chronic hypoxia) can
lead to right heart failure and pulmonary
oedema. Acute HPV can arise from any clinical
condition which results in alveolar hypoxia e.g.
causes of airway obstruction including asthma,
ventilatory insufficiency caused by neurological
defects,...

In 1996, in Curacao, a small island in the
Netherlands Antilles, ten patients of a hemodialysis
center died because of an outbreak of subacute
aluminum intoxication. Two aspects were responsible
for this intoxication. First, no water purification
system was used in the dialysis center. In
hemodialysis treatment many liters water are used.
The water has to be pure because substances
dissolved in the water can enter the blood
compartiment of the patients. Because very pure
distilled seawater was used for the distribution of
drinking water in those island it was common
practice not...

Over the past decade, the metabolic syndrome has
increased dramatically in the population and its
contribution to the development of cardiovascular
disease has grown in parallel. This is an ongoing
situation, and as a consequence, metabolic
abnormalities encompassed by the metabolic syndrome,
such as dyslipidemia, obesity and insulin
resistance, constitute a major threat to public
health. Although the metabolic syndrome has its
limitations as a clinical diagnosis, there is a need
to improve our understanding of its aetiological
link to cardiovascular disease in order to identify...

The Finnish Rheumatoid Arthritis Combination-Therapy Trial performed from 1993 to 2000 investigated the efficacy of a combination of three disease-modifying antirheumatic drugs (DMARDs) compared to a single DMARD. Patients with recent-onset active RA were randomized to the two treatment arms for 2 years, after which drug-treatment strategy became unrestricted. At baseline, 162 patients were available for work. After a 5-year follow-up, objective data on sick leave and retirement were gathered from social insurance registers, . The cumulative number of days off work was calculated. The...

Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

• Leading experts from academia and clinical laboratory science
• Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies