In 1993, the genetic mutation responsible for Huntington s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene.

Neurobiology of Huntington s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and...