This book includes many of the papers presented at the 6th International workshop on Model Oriented Data Analysis held in June 2001. This series began in March 1987 with a meeting on the Wartburg near Eisenach (at that time in the GDR). The next four meetings were in 1990 (St Kyrik monastery, Bulgaria), 1992 (Petrodvorets, St Petersburg, Russia), 1995 (Spetses, Greece) and 1998 (Marseilles, France). Initially the main purpose of these workshops was to bring together leading scientists from 'Eastern' and 'Western' Europe for the exchange of ideas in theoretical and applied statistics, with...

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.

After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover...