This text is a volume in the Methods and New Frontiers in Neuroscience series. Initally confined to behavioural studies, the field of drug addiction and substance abuse has broadened dramatically to include a vast array of cellular and molecular approaches as well as sophisticated electrophysiological, neurochemical, and imaging methodologies. This text assembles this information, providing detailed descriptions of proceedures as well as methods and equipment used to conduct experiments that use multiple technical approaches. Topics include: brain reward mechanisms in the addictive process;...