This volume contains the proceedings of the Alexandre Vinogradov Memorial Conference on Diffieties, Cohomological Physics, and Other Animals, held from December 13-17, 2021, at the Independent University of Moscow and Moscow State University, Moscow, Russia. The papers are devoted to various interrelations of nonlinear PDEs with geometry and integrable systems. The topics discussed are: gravitational and electromagnetic fields in General Relativity, nonlocal geometry of PDEs, Legendre foliated cocycles on contact manifolds, presymplectic gauge PDEs and Lagrangian BV formalism, jet geometry...