This book constitutes the refereed proceedings of the 12th Enterprise Engineering Working Conference on Advances in Enterprise Engineering XVI, EEWC 2022, held in Leusden, The Netherlands, November 2-3, 2022. EEWC aims at addressing the challenges that modern and complex enterprises are facing in a rapidly changing world. The participants of the working conference share a belief that dealing with these challenges requires rigorous and scientific solutions, focusing on the design and engineering of enterprises. The goal of EEWC is to stimulate interaction between the different...