This book constitutes the thoroughly refereed proceedings of the international workshops associated with the 34th International Conference on Advanced Information Systems Engineering, CAiSE 2022, which was held in Leuven, Belgium, during June 6-10, 2022.The workshops included in this volume are: * BC4IS: Second International Workshop on Blockchain for Information Systems * ISESL: Second International Workshop on Information Systems Engineering for Smarter Life * KET4DF: 4th International Workshop on Key Enabling Technology for Digital Factories They...